Results 141 to 150 of about 3,701,355 (246)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
WTO direct action convergence, Seattle, WA (nov. 20-28), registration application [verso]
, 1999 Alternate title: DAN registration. Affiliated web page url: www.agitprop.org/artandrevolution/wto. Also sent out as document 6 of 19 in a Direct Action Network (DAN) organizing packet; these documents are contained in a 9 X 12 inch envelope stating ...
Direct Action Network (DAN)
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Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Education Research: Comparison of Lecture-Based and Direct Instruction Didactics to Improve Neurologic Examination Confidence in Neurology Clerkship Students. [PDF]
Neurol EducTrout J +3 more
europepmc +1 more source
, 1999 Alternate title: Resist the World Trade Organization roadshow. Also sent out as document 12 of 19 in a Direct Action Network (DAN) organizing packet; these documents are contained in a 9 X 12 inch envelope stating approximately 50-100 organizing packets
Direct Action Network (DAN)
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Monthly Bulletin of the State Department of Public Instruction, 1952
, 1952 Publication information Monthly during school yearFloyd Souders and Mrs. Hazel Bixby Appointed to State Board of Education Children's Dental Health Day To Be Observed on February 4 Handbook for School Board Members Published by League of Kansas ...
Kansas State Department of Public Instruction
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