Results 81 to 90 of about 12,314,088 (295)

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Assessment of Out of Pocket Cost Born by Patients of Type 2 Diabetes Mellitus in Private Diabetic Clinics of Islamabad

Journal of Islamic International Medical College, 2015
Objective: To estimate the direct cost and its determinants in type2 diabetic patients visiting outpatient department of private tertiary care hospitals. Study Design: A descriptive cross sectional study.
Sidra Malik , Danish Nadeem , Saima Hamid , Jamal Zafar , Shahzad Ali Khan , Waheed Iqbal , Tabinda Zaman
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Determining direct, indirect healthcare and social costs for diabetic retinopathy management: a systematic review

BMC Ophthalmology
Introduction Diabetic retinopathy (DR) is a rapidly growing global public health threat; it affects 1 in 3 people with diabetes and is still the leading cause of blindness among the working-age population.
Mawdda Benhamza, Maznah Dahlui, Mas Ayu Said   +2 more
doaj   +1 more source

The cost of unresectable stage III or stage IV melanoma in Italy

Journal of Experimental & Clinical Cancer Research, 2012
Background In recent decades, melanoma incidence has been increasing in European countries; in 2006, there were approximately 60,000 cases leading to 13,000 deaths. Within Europe there is some geographical variation in the incidence of melanoma, with the
Maio Michele, Ascierto Paolo, Testori Alessandro, Ridolfi Ruggero, Bajetta Emilio, Queirolo Paola, Guida Michele, Romanini Antonella, Chiarion-Sileni Vanna, Pigozzo Jacopo, Di Giacomo Anna Maria, Calandriello Mario, Didoni Guido, van Baardewijk Marck, Konto Cyril, Lucioni Carlo   +15 more
doaj   +1 more source

Annual direct cost of dry eye in Japan

, 2012
Yoshinobu Mizuno, Masakazu Yamada, Chika ShigeyasuDivision for Vision Research, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, JapanOn behalf of The Dry Eye Survey Group, National Hospital Organization of JapanBackground ...
Shigeyasu C, Mizuno Y, Yamada M
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Direct medical costs of polyarthritis in a pediatric hospital in Mexico

Boletín Médico del Hospital Infantil de México
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. The polyarticular course (polyarthritis) represents 63-66% of patients with JIA. The aim was to determine the direct medical costs (DMC) of JIA of the polyarthritis type in pediatric patients of a tertiary hospital in Mexico.An analysis of the disease costs was ...
María F. Carrillo-Vega, Juan M. Mireles-Dorantes, Samara Mendienta-Zerón, Guillermo Salinas-Escudero, Filiberto Toledano-Toledano, Victor Granados-García   +5 more
openaire   +3 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Economic Burden of Rheumatoid Arthritis in Iran: A Societal Perspective

Public Health Challenges
Background Rheumatoid arthritis (RA) is a progressive and chronic systemic inflammatory disease and imposes a significant economic burden on patients and societies if not controlled. This study aimed to determine the economic burden of RA in Iran in 2022.
Mehdi Rezaee, Farhad Lotfi, Ahmad Gholami, Jassem Azizpoor, Elham Aflaki, Afsaneh Vazin, Khosro Keshavarz   +6 more
doaj   +1 more source