Results 61 to 70 of about 8,519,610 (290)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

Advanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang   +5 more
wiley   +1 more source

Near‐Unity Selectivity Inversion Between CO2 Electroreduction and H2 Evolution via Atomic Coordination Editing

Advanced Science, EarlyView.
Atomic coordination editing functions as an on/off switch that toggles single‐atom catalysts between CO2 electroreduction and hydrogen evolution. ABSTRACT Precise atomic coordination editing of single‐atom catalysts (SACs) provides an effective strategy to tune their electronic structures and catalytic selectivity. Yet, achieving near‐unity selectivity
Yukun Zhao, Yuanyuan He, Mengyu Duan, Peng Yin, Jinxing Chen, Xu Han, Jie Yang, Yulin Wang, Xingjie Fu, Shibo Xi, Chuncheng Chen, Jiong Lu   +11 more
wiley   +1 more source

Diaphragm air–liquid micro pump applicable to the direct methanol fuel cell

, 2014
This study developed a diaphragm aireliquid micro pump applicable to direct methanol fuel cells. Because direct methanol fuel cells use liquid methanol as fuel and the cathode terminal of the fuel cell uses an active air supply, improving the operational
Lee, Shi-Min; Kuan, Yean-Der; Sung, Min-Feng, Lee, Shi-Min   +1 more
core   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Recent developments in passive direct methanol fuel cells

, 2017
Direct methanol fuel cells (DMFCs) are in the Energy Agenda due to their market potential to replace the conventional batteries in portable applications, either for recreational, professional, military and medical purposes, since they enable the direct ...
Vânia B. Oliveira, Alexandra M. F. R. Pinto, Beatriz A. Braz   +2 more
core   +1 more source

Increasing Fuel Efficiency of Direct Methanol Fuel Cell Systems with Feedforward Control of the Operating Concentration

Energies, 2015
Most of the R&D on fuel cells for portable applications concentrates on increasing efficiencies and energy densities to compete with other energy storage devices, especially batteries.
Youngseung Na, Federico Zenith, Ulrike Krewer   +2 more
doaj   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Rich-grain-boundary PtRuNi with network structure as efficient catalysts for methanol oxidation reaction

International Journal of Electrochemical Science, 2019
Fabricating a network structure is an efficient way to increase the electrocatalytic activity of a catalyst. In this study, a network-like structure of PtRuNi with rich grain boundaries characterized via scanning electron microscopy and transmission ...
Zi-ning Wang, Shu-hui Huo, Peng-xin Zhou
doaj   +1 more source

Probing Electrocatalyst Design for Product Selectivity in CO2 Reduction

Advanced Science, EarlyView.
Selective CO2 electroreduction is controlled by catalyst structure, dynamic surface reconstruction, adsorbate interactions, and reaction microenvironment. This review summarizes Cu‐ and non‐Cu‐based catalysts, single‐atom and molecular systems, degradation pathways, and operando/computational strategies for steering CO2RR toward hydrocarbons ...
Suvodeep Sen, Bapan Biswas, Apinya Ngoipala, Julia Wiktor, Ujjwal Pal, Shalini Singh   +5 more
wiley   +1 more source

Effect of Vibration on Open-Cathode Direct Methanol Fuel Cell Stack Performance

Physchem
This study investigates the impact of vibration frequency on the performance of a 10-cell open-cathode direct methanol fuel cell (OC-DMFC) stack. Experiments were conducted using three different vibration frequencies (15, 30, and 60 Hz) and compared ...
Selahattin Celik, Gamze Atalmis Sari, Mikail Yagiz, Hasan Özcan, Bahman Amini Horri   +4 more
doaj   +1 more source