Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Approximations of solutions for a class of conditionally well-posed integro-differential equations
Учёные записки Казанского университета: Серия Физико-математические наукиIn this article, for a specific class of conditionally well-posed integro-differential equations in a novel pair of weighted Sobolev spaces, an alternative method for constructing approximations (particularly finite-dimensional ones) to the solution of ...
J. R. Agachev, M. Yu. Pershagin
doaj +1 more source
A direct method to quantify methanol-soluble organic carbon for brown carbon absorption studies. [PDF]
MethodsX, 2023 Paraskevopoulou D +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
CrystalsIn protein crystallography, the determination of an accurate protein envelope is of paramount importance for ab initio phasing of diffraction data. In our previous work, we introduced an approach to ascertain the protein envelope by seeking an optimal ...
Ruijiang Fu, Wu-Pei Su, Hongxing He
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When a Straight Line Is Not the Most Direct Method: an Evaluation of Straight Line Versus True Distance Metrics for Patients in Rural Settings. [PDF]
J Behav Health Serv Res, 2023 Ludrosky JM +4 more
europepmc +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
A direct method for the identification of patterns of care using administrative databases: the case of breast cancer. [PDF]
Eur J Health Econ, 2021 Busco S +10 more
europepmc +1 more source
Direct Method for Training Feed-forward Neural Networks using Batch Extended Kalman Filter for Multi-Step-Ahead Predictions [PDF]
, 2016 Artem Chernodub
openalex +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source