Results 91 to 100 of about 21,516,320 (280)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Total direct non-medical and indirect, and societal costs by discharge medical diagnosis (n = 647).

, 2018
Total direct non-medical and indirect, and societal costs by discharge medical diagnosis (n = 647).
Peter MacPherson (2827067), Hendramoorthy Maheswaran (186758), Danielle Cohen (4966297), Stavros Petrou (3468155), Elizabeth L. Corbett (232781), David G. Lalloo (101770), Aileen Clarke (470453), Felistas Kumwenda (3549965)   +7 more
core   +1 more source

The societal impact of treatment with natalizumab of relapsing–remitting multiple sclerosis in Italian clinical practice: The Tysabri PharmacoEconomics (TyPE) Study

Global & Regional Health Technology Assessment, 2019
Multiple sclerosis progressively impairs patients’ ability to independently perform activities of daily living, reduces working capacity, and negatively affects social interactions and relationships, imposing a cost for the society. The aim of this study
B Polistena, F Spandonaro, R Capra, S Fantaccini, L Santoni, GB Zimatore, C Gasperini   +6 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

The economic burden of tuberculosis in Cyprus. A probabilistic cost of illness study.

Epidemiology, Biostatistics and Public Health, 2018
Background: Tuberculosis remains a major public health problem with considerable economic burden worldwide. The aim of this study was to estimate the economic burden of tuberculosis in Cyprus during 2009.
Savvas Zannetos, Theodora Zachariadou, Tonia Adamidi, Andreas Georgiou   +3 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

DIRECT HEALTHCARE COSTS OF DIABETES MELLITUS PATIENTS IN SPAIN [PDF]

Objectives. To estimate the healthcare resources spent by diabetic patients in Spain during the year 2002. Methods. The present work is a cost-of-illness study.
Begoña Molina, Juan Oliva, Félix Lobo, Susana Monereo   +3 more
core  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The cost-effectiveness of an early interventional strategy in non-ST-elevation acute coronary syndrome based on the RITA 3 trial [PDF]

, 2008
The published version of the aritcle can be found at the link below.Background: Evidence suggests that an early interventional strategy for patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) can improve health outcomes but also increase ...
Sculpher, Mark,, Sculpher, MJ, Henriksson, M, Clayton, TC, Epstein, DM, Palmer, Stephen,, Fox, KAA, Henderson, Robert,, Pocock, SJ, Henriksson, Martin,, Epstein, David,, Buxton, Martin,, Palmer, SJ, Henderson, RA, Clayton, Tim,, Pocock, Stuart,, Fox, Keith A. A.,, Buxton, MJ   +17 more
core   +1 more source

Estimation of Attributable Risk and Direct Medical and Non-Medical Costs of Major Mental Disorders Associated With Air Pollution Exposures Among Children and Adolescents in the Republic of Korea, 2011–2019

Journal of Korean Medical Science
Recent studies have reported the burden of attention deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and depressive disorder. Also, there is mounting evidence on the effects of environmental factors, such as ambient air pollution, on these disorders among children and adolescents. However, few studies have evaluated the burden of
Yae Won Ha, Tae Hyun Kim, Dae Ryong Kang, Ki-Soo Park, Dong Chun Shin, Jaelim Cho, Changsoo Kim   +6 more
openaire   +2 more sources