Results 61 to 70 of about 504,051 (284)

Table_1_Measuring direct non-medical burden among patients with advanced non-small cell lung cancer in China: is there a difference in health status?.pdf

, 2023
ObjectiveThis study was conducted to estimate the direct non-medical cost of advanced non-small cell lung cancer (NSCLC) patients and explore whether its associated factors vary by health status.MethodsData were obtained from 13 centers in five provinces
Yingyao Chen (3466658), Jia Chen, Yuying Gan, Chunxia Su, Chunxia Su (423328), Enwu Long (11195208), Yi Yang (116183), Yingyao Chen, Yu Xia, Enwu Long, Fei Yan, Yi Yang, Haibo Zhang, Haibo Zhang (5720), Yu Xia (8822), Fei Yan (128878), Jia Chen (8203), Yuying Gan (11678059)   +17 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Economic evaluation of ASCOT-BPLA: Antihypertensive treatment with an amlodipine-based regimen is cost-effective compared to an atenolol-based regimen

, 2007
Copyright © 2010 BMJ Publishing Group Ltd & British Cardiovascular Society. Internal or personal use of this material is permitted. However, permission to reprint/republish this material must be obtained from the Publisher.Objective: To compare the cost ...
T Kahan, N R Poulter, Dahlof, B, M Buxton, B Jonsson, B Dahlof, H Wedel, Sever, PS, null null, Wedel, H, Kahan, T, Lindgren, P, P Lindgren, Jönsson, B, Buxton, MJ, P S Sever, Poulter, NR   +16 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Economic Burden of Rheumatoid Arthritis in Iran: A Societal Perspective

Public Health Challenges
Background Rheumatoid arthritis (RA) is a progressive and chronic systemic inflammatory disease and imposes a significant economic burden on patients and societies if not controlled. This study aimed to determine the economic burden of RA in Iran in 2022.
Mehdi Rezaee, Farhad Lotfi, Ahmad Gholami, Jassem Azizpoor, Elham Aflaki, Afsaneh Vazin, Khosro Keshavarz   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Productivity losses and treatment cost of benign prostatic hyperplasia in Ghana.

PLoS ONE
Benign Prostatic Hyperplasia (BPH) is a common condition among ageing men, characterized by lower urinary tract symptoms that significantly impact the quality of life and economic productivity of affected individuals.
Daniel Senanu Dadee-Seshie, Sedem Godson Agbeteti, Banabas Kpankyaano, Aishah Fadila Adamu, Selase Kofi Adanu, Yakubu Alhassan, Maxwell Ayindenaba Dalaba, Kekeli Kodjo Adanu   +7 more
doaj   +1 more source

Social-economic burden of Pompe disease with late onset in the Russian Federation

Качественная клиническая практика, 2019
Pompe disease (PD) — a rare disease with progressive muscles weakness, cardiac and pulmonary insufficiency and others vital life-threatening symptoms without enzyme replacement therapy (ERT).
A. S. Kolbin, I. A. Vilyum, Yu. E. Balikina, M. A. Proskurin, O. I. Karpov   +4 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source