Results 61 to 70 of about 21,516,320 (280)

Economic Burden of Rheumatoid Arthritis in Iran: A Societal Perspective

Public Health Challenges
Background Rheumatoid arthritis (RA) is a progressive and chronic systemic inflammatory disease and imposes a significant economic burden on patients and societies if not controlled. This study aimed to determine the economic burden of RA in Iran in 2022.
Mehdi Rezaee, Farhad Lotfi, Ahmad Gholami, Jassem Azizpoor, Elham Aflaki, Afsaneh Vazin, Khosro Keshavarz   +6 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Raw cost and meta-analysis of direct medical costs.^†

, 2016
Raw cost and meta-analysis of direct medical costs.†
Lan Gao (61471), Shu-Chuen Li (2185669), Fei-Li Zhao (2185666), Hao Hu (111737)   +3 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Assessment of Direct Medical Cost of Hospitalized COVID-19 Adult Patients in Kuwait During the First Wave of the Pandemic [PDF]

Sarah A AlManie,1 Mai S AlHazami,1 Alyah Ebrahim,2 Muhammad S Attique2 1Department of Pharmacy Practice, School of Pharmacy-Kuwait University, Kuwait City, Kuwait; 2Respiratory Department- Jaber Al-Ahmad Al-Sabah Hospital, Kuwait City ...
AlHazami MS, AlManie SA, Attique MS, Ebrahim A   +3 more
core  

Productivity losses and treatment cost of benign prostatic hyperplasia in Ghana.

PLoS ONE
Benign Prostatic Hyperplasia (BPH) is a common condition among ageing men, characterized by lower urinary tract symptoms that significantly impact the quality of life and economic productivity of affected individuals.
Daniel Senanu Dadee-Seshie, Sedem Godson Agbeteti, Banabas Kpankyaano, Aishah Fadila Adamu, Selase Kofi Adanu, Yakubu Alhassan, Maxwell Ayindenaba Dalaba, Kekeli Kodjo Adanu   +7 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Cost-effectiveness in clinical trials : using multiple imputation to deal with incomplete cost data [PDF]

, 2007
Background: Cost-effectiveness has become an important outcome in many clinical trials and has resulted in the collection of resource use data and the calculation of costs for individual patients.
Burton, Andrea, Billingham, Lucina Jane, Bryan, Stirling, Billingham, Lucinda; id_orcid, Burton, A   +4 more
core   +1 more source

Cost-effectiveness of alternativestrategies for the initial medical management of non-ST elevation acute coronary syndrome: systematic review and decision-analytical modelling

, 2005
Cost-effectiveness of alternativestrategies for the initial medical management of non-ST elevation acute coronary syndrome: systematic review and decision-analytical ...
S. Palmer (3693193), A. Pearman (7583702), D. Gray (3981596), K. Alfakih (7583693), A. Bakhai (7583696), A. Eastwood (3968654), C. Packham (7583699), M. Robinson (3555968), Mark J. Sculpher (4730214), A. Bowens (7583687), S. Golder (7583690), Z. Philips (7583681), M. Flather (7583705), Keith R. Abrams (7579436), A. Hall (7131740), L. Ginnelly (7583684), N. Cooper (7171460)   +16 more
core   +4 more sources