Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Predicting Drag-Reducing Wall Turbulence of Surfactant Solution by Direct Numerical Simulation
We performed direct numerical simulations (DNS) of turbulent channel flow of surfactant solution to investigate characteristics of modulated wall turbulence and turbulent drag reduction.
Takashi OHTA +2 more
doaj +1 more source
Direct numerical simulation of an unsteady wall-bounded turbulent flow configuration for the assessment of large-eddy simulation models. [PDF]
Engelmann L +4 more
europepmc +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
Direct numerical simulation of the turbulent flow generated during a violent expiratory event. [PDF]
Fabregat A +5 more
europepmc +1 more source
Direct numerical simulations of spots
Although many properties of turbulent spots have been determined by laboratory measurements and flow visualization, there still remain unanswered questions about the mechanisms involved in the spreading of spots, the role of instability waves, and the structure of the turbulent flow within and the non-turbulent but modified flow outside spots, Direct ...
Mathew, Joseph, Das, Arup
openaire +1 more source
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi +9 more
wiley +1 more source
Understanding entrainment processes in the atmosphere: the role of numerical simulation [PDF]
Turbulent entrainment is a process of primary importance in the atmospheric boundary layer; however despite several decades of intense study much remains to be understood.
Jonker, Harm JJ, van Reeuwijk, Maarten
core +1 more source
Direct numerical simulation of turbulent dispersion of evaporative aerosol clouds produced by an intense expiratory event. [PDF]
Fabregat A +6 more
europepmc +1 more source

