Results 251 to 260 of about 6,172,609 (305)

Direct observation of V-trimers in the crystal structure of LiVO₂. [PDF]

Commun Chem
Yun S, Chang CF, Chen SH, Kuo CY, Tjeng LH, Komarek AC.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Direct Observation of Infanticide by a Female Free-Ranging Dog (<i>Canis familiaris</i>) Supports the Resource Competition Hypothesis. [PDF]

Ecol Evol
Vanderheyden M, Chaignon B, Car C, Pilot M, El Berbri I, Marshall-Pescini S, Range F, Berghänel A.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Direct Observation of the Exciton-Polaron in Single CsPbBr₃ Quantum Dots. [PDF]

ACS Nano
Shen Z, Samoli M, Erdem O, Bielecki J, Samanta AK, E J, Estillore AD, Kim C, Kim Y, Koliyadu J, Letrun R, Locardi F, Lübke J, Mall A, Melo DVM, Mills G, Rafie-Zinedine S, Round A, Sato T, de Wijn R, Wollweber T, Worbs L, Zhuang Y, Mancuso AP, Bean R, Chapman HN, Küpper J, Infante I, Lange H, Hens Z, Ayyer K.   +30 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Direct observation of two-channel photodissociation of carbon monoxide from the hemoglobin subunits. [PDF]

Nat Commun
Lepeshkevich SV, Sazanovich IV, Parkhats MV, Gilevich SN, Yantsevich AV, Weinstein JA, Towrie M, Dzhagarov BM.   +7 more
europepmc   +1 more source

Implementation of DOPS (Direct Observation of Procedural Skills) as formative assessment tool to enhance procedural skills in anesthesia postgraduate students. [PDF]

Saudi J Anaesth
Gupta N, Saxena D, Malviya S.
europepmc   +1 more source

Direct Observation of Ascorbyl Free Radicals in Whole Blood of Goats During Cardiac Surgery With Cardiopulmonary Bypass. [PDF]

Cureus
Tokumaru O, Matsumoto S, Mizoguchi T, Ogata K, Okamoto K, Kawashima T, Anai H, Miyamoto S, Kitano T.   +8 more
europepmc   +1 more source

Direct observation and measurement of the average quantum methyl-tunneling frequency in a protein using <i>T</i>_m-edited double electron-electron resonance EPR spectroscopy. [PDF]

Chem Commun (Camb)
Schmidt T, Torricella F, Clore GM.
europepmc   +1 more source