Results 251 to 260 of about 1,512,078 (302)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Direct Observation of Triplet-Triplet Energy Transfer in DNA between Energy Donor and Acceptor C‑Nucleotides. [PDF]

JACS Au
Häcker S, Zähringer TJB, Wagenknecht HA, Kerzig C.   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Direct observation and control of non-classical crystallization pathways in binary colloidal systems. [PDF]

Nat Commun
Zang S, Paul S, Leung CW, Chen MS, Hueckel T, Hocky GM, Sacanna S.   +6 more
europepmc   +1 more source

Direct Observation of Secondary Nucleation in Huntingtin Amyloid Formation by High-Speed Atomic Force Microscopy. [PDF]

J Am Chem Soc
van Ewijk C, Jain G, Knelissen YK, Maity S, van der Wel PCA, Roos WH.   +5 more
europepmc   +1 more source

Direct observation and force modulation of single-bond reactions at the ion/metal interface. [PDF]

Sci Adv
Zhao C, Li K, Hao J, Wang Y, He H, Jia C, Guo X.   +6 more
europepmc   +1 more source

Direct Observation of Anisotropic Coulomb Interaction in a Topological Nodal Line Semimetal. [PDF]

Adv Sci (Weinh)
Kim HW, Jung J, Lee G, Park T, Jang WJ, Kim H, Kim JS, Shim JH, Yang BJ, Jeon S.   +9 more
europepmc   +1 more source

The reality of neonatal nursing work in Kenya and implications for quality and safety: Direct observation of tasks and time utilisation.

Int J Nurs Stud
Onyango O, Kagonya VA, Maina M, Karumba K, Imam A, Fuller SS, Gathara D, English M, HIGH-Q Hospital Group.   +8 more
europepmc   +1 more source

Direct observation of fluorescent proteins in gels: A rapid, cost-efficient, and quantitative alternative to immunoblotting. [PDF]

Biol Cell
Sanial M, Miled R, Alves M, Claret S, Joly N, Proux-Gillardeaux V, Plessis A, Léon S.   +7 more
europepmc   +1 more source

Direct observation of the neural computations underlying a single decision. [PDF]

Elife
Steinemann N, Stine GM, Trautmann E, Zylberberg A, Wolpert DM, Shadlen MN.   +5 more
europepmc   +1 more source