Results 141 to 150 of about 4,435,862 (297)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Impact of prior oral anticoagulation on admission stroke severity in patients with atrial fibrillation

Biomedical Papers
Background and Aims. In patients with atrial fibrillation, oral anticoagulation therapy is indicated for both primary and secondary prevention of stroke/systemic embolism.
David Franc, Daniel Sanak, Michal Kral, Martin Hutyra, Milos Taborsky, Petra Divisova, Jana Zapletalova   +6 more
doaj   +1 more source

Investigation of the effects of direct factor Xa inhibitor novel oral anticoagulants by viscoelastic test

Laboratory monitoring of direct factor Xa inhibitor novel oral anticoagulants (DOAC) is not mandatory however, it is useful in certain clinical situations including acute care, especially before interventional procedures.
Noguchi, Fuka
core  

Chlorfenapyr Induces Hepatotoxicity Associated With Oxidative Stress and Mitochondrial Dysfunction Involving Keap1/Nrf2 Signaling

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao, Jia Li, Cheng Li, Hua He, Lipu Deng   +4 more
wiley   +1 more source

Reversal Agents for Direct Oral Anticoagulants

, 2019
Anticoagulation is a necessary component of modern healthcare and is used to treat thromboembolic conditions such as venous thromboembolism (VTE) and pulmonary embolism (PE), prevent stroke in patients with atrial fibrillation (AF), and more.
Pennisi, Megan, MPAM, PA-C, McCann, Lindsay, PharmD, BCCCP   +1 more
core   +1 more source

Platelet‐Rich Fibrin (PRF) Application and Education in US Graduate Programs: A Cross‐Sectional Study

Journal of Dental Education, EarlyView.
ABSTRACT The aim of this cross‐sectional study was to assess platelet‐rich fibrin (PRF) application and education in clinical use among US graduate periodontology, endodontic, and oral and maxillofacial surgery programs. A survey questionnaire was electronically distributed to 84 oral and maxillofacial surgery (OMFS), 46 endodontic, and 46 ...
Elena Furman, Mark Piroutek, T. Roma Jasinevicius, Andre Paes B. da Silva   +3 more
wiley   +1 more source

Evaluating the impact of a newly established hospitalist medicine procedure service on length of stay and procedural outcomes: A retrospective propensity‐matched analysis

Journal of Hospital Medicine, EarlyView.
Abstract Background Reliance on interventional radiology (IR) has been associated with delays in procedure completion and prolonged hospital length of stay (LOS). Hospitalist medicine procedure services (HMPS) have been proposed as a strategy to mitigate these inefficiencies, though outcomes of newly established programs composed of physicians with ...
Jeremy Gentile, Saria Alazmeh, Kriti Soni, Tarek Alsibai, Felicia Wright, Alicia Stowe, Fergus Peacock   +6 more
wiley   +1 more source

A framework for integrating health‐related social needs education into electronic health record clinical pathways

Journal of Hospital Medicine, EarlyView.
Abstract Health‐related social needs (HRSN) significantly influence patient outcomes, yet they are rarely integrated into point‐of‐care decision‐making. We developed a process to embed HRSN‐informed and HRSN‐targeted care recommendations directly into three electronic health record‐integrated high‐use clinical pathways—cirrhosis, diabetes, and ...
Karthik Warke Rohatgi, Siddhi Nadkarni, Nisarg Shah, Lou Hart, Dan Heacock, Shaili Gupta   +5 more
wiley   +1 more source

Factors associated with prescription of oral anticoagulants in the era of direct oral anticoagulants

Clinical Cardiology, 2023
Naoya Kataoka, Teruhiko Imamura
openaire   +2 more sources