Results 111 to 120 of about 100,234 (286)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Power domination in product graphs

open access: yes, 2008
International audienceThe power system monitoring problem asks for as few as possible measurement devices to be put in an electric power system. The problem has a graph theory model involving power dominating sets in graphs.
Mollard, Michel   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

A Highly Selective and Sensitive Spectrofluorimetric Method for the Determination of N-acetyl-4-aminophenol at Nano-trace Levels in Pharmaceuticals and Biological Fluids Using Cerium (IV)

open access: yesPakistan Journal of Analytical & Environmental Chemistry, 2019
A very simple, rapid, ultra-sensitive, highly selective and non-extractive spectrofluorimetric method for the determination of N-acetyl-4-aminophenol (paracetamol) at ultra-trace levels has been developed.
M. Jamaluddin Ahmed   +2 more
doaj   +1 more source

The Automorphism Group of the Wreath Product of Directed Graphs

open access: yesEuropean Journal of Combinatorics, 1980
We give necessary and sufficient conditions for the automorphism group of the wreath product of directed graphs to be the wreath product of their respective automorphism groups. This gives a generalization of a theorem of Sabidussi.
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

On a Vizing-like conjecture for direct product graphs

open access: yes, 1996
Let γ(G) be the domination number of a graph G, and let G × H be the direct product of graphs G and H. It is shown that for any k ⩾ 0 there exists a graph G such that γ(G × G) ⩽ γ(G)2 − k. This in particular disproves a conjecture from [5]
Klavẑar, Sandi   +3 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Hyper-Zagreb index in fuzzy environment and its application

open access: yesHeliyon
The Zagreb indices (ZIs) are important graph invariants that are used extensively in many different fields in mathematics and chemistry, such as network theory, spectral graph theory, fuzzy graph theory (FGT) and molecular chemistry, etc. The hyper-ZI is
Sk Rabiul Islam   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy