E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
An Impact Load History Reconstruction Method for Composite Structures Based on FBG Sensing Data and the GCV Principle. [PDF]
Sensors (Basel)Zeng J +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
From concrete to canopy: Illuminating moth biodiversity in New York City's urban jungle. [PDF]
PLoS OneLinsk S, Thonis A, Winchell KM.
europepmc +1 more source
Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires [PDF]
, 2019 Jiyun Lim +6 more
openalex +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Comparison of skin microbiota profiles in chronic scratch lesions using tape strip and swab sampling. [PDF]
JAAD IntKeum HL, Sul WJ, Kim HS.
europepmc +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Effect of direct mailing self-sampling kits on participation in the Dutch hrHPV-based cervical screening programme: a population-based study. [PDF]
Lancet Reg Health EurOlthof EMG, Siebers AG, de Kok IMCM.
europepmc +1 more source