Results 211 to 220 of about 823,786 (262)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Integrating Advanced Endoscopic Techniques and Confocal Microscopy for Early Detection of Extrahepatic Cholangiocarcinoma. [PDF]

Cancers (Basel)
Lattanzi B, Covotta F, Crescenzi A, Lamazza A, Di Matteo FM, Alvaro D, Cardinale V.   +6 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Minimizing discard volume to 2 ml before blood sampling from a central venous catheter: a prospective observational study in India. [PDF]

Acute Crit Care
Pushparaj A, Ramamoorthy L, S MA, Murugesan R, Lalthanthuami HT.   +4 more
europepmc   +1 more source

Exploring effectiveness of two common trap designs for capturing fish diversity in small freshwater bodies. [PDF]

Environ Monit Assess
Thomas K, Gottwald M, Bartoň D, Šmejkalová Z, Šmejkal M.   +4 more
europepmc   +1 more source

<i>Neospora caninum</i> infection and reproductive disorders in Creole goats from southern Peru: A Bayesian mediation analysis across agroecological zones. [PDF]

Vet World
Soca J, Trillo-Salvador M, Valdivia-Zevallos J, Canchino-Gutierrez J, Sessarego EA, Mendoza-Alacute E, Temoche-Socola V, Cruz-Luis J, Cruz DJ.   +8 more
europepmc   +1 more source

Potential Release of Micro- and Nanoplastics from Stormwater Infrastructure. [PDF]

ACS ES T Water
Doti B, Gray A, Strom K, Foroutan H.
europepmc   +1 more source

Long-term photovoltaic succession promotes preferential ammonium accumulation in desert ecosystems. [PDF]

iScience
Xiao J, Wang A, Tian Y, Tan Q, Chen T, Liu F, Cai Z, Ma S, Sun F, Yang H, Chen L.   +10 more
europepmc   +1 more source