Results 91 to 100 of about 730,650 (301)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Advancements in Digital Workflows for 3D-Printed Maxillofacial Soft Prostheses: Exploring Design and Materials in Direct Additive Manufacturing: A Scoping Review

Applied Sciences
The treatment of maxillofacial defects presents significant challenges due to the complexity of facial anatomy and the diversity of affected tissues. Traditional workflows are labor-intensive, costly, and limited in customization.
Cristian Ioan Tarba, Mircea Alexandru Cristache, Ioana Medeea Baciu, Corina Marilena Cristache, Oana Elena Burlacu Vatamanu, Luminita Oancea   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Informal Job Search and Black Youth Unemployment [PDF]

In this paper I analyze how young black and white unemployed jobseekers use various methods of search, and the employment outcomes which result from their use.The focus is on distinguishing informal search methods (i.e.,friends and relatives or direct ...
Harry J. Holzer
core  

Direct search methods using orthogonal directions: the Rosenbrock method and the David, Swann, and Campey method [PDF]

, 1988
The Rosenbrock Algorithm and the D. S. C. Algorithm, both direct search methods using orthogonal directions were implemented into a software. Values of the optimal parameters were determined and the performance was compared with each other and with the ...
San Luis, Jonas Marcos B
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Over‐the‐Horizon Direct Positioning With Ionospheric Heights Priors

IET Radar, Sonar & Navigation
This study addresses positioning errors in high‐frequency (HF) over‐the‐horizon (OTH) localisation that arise from inaccuracies in ionospheric virtual height measurements.
Shuyu Zheng, Haiying Zhang, Xiuquan Dou
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Quantum Enhancements for Direct Search Methods [PDF]

This dissertation explores the use of quantum search algorithms to im- prove direct search methods for single and multiobjective optimization. Quantum search algorithms are known to reduce the expected number of oracle calls needed to find the solution ...
Mikes, Colton
core