Results 71 to 80 of about 730,500 (301)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Job-search Methods, Neighbourhood Effects and the Youth Labour Market [PDF]
Survey data suggest that unemployed teenagers look for work in ways that differ significantly from the ways which proved successful for teenagers who found work.
Alexandra Heath
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Solution of Different Types of Economic Load Dispatch Problems Using a Pattern Search Method
, 2008 Direct search (DS) methods are evolutionary algorithms used to solve constrained optimization problems. DS methods do not require information about the gradient of the objective function when searching for an optimum solution.
Sykulski, J.K. +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Which one to choose? New evidence on the choice and success of job search methods [PDF]
This paper provides new evidence on the choice and success of six different job search channels comprising the public employment agency, advertisements in newspapers and journals, internet job search, recruitment agencies, direct applications, and the ...
Mick Wittich, Stephan Thomsen
core
Direct search methods in the optimisation of cancer chemotherapy regimens [PDF]
British Journal of Cancer, 1990 Current cancer chemotherapy regimens may involve 20-30 or more independent variables, each affecting therapeutic response and toxicity. With standard response surface modelling methods, finding the optimum combination with as few as 10 variables entails testing over 1,000 combinations, so these methods do not provide a feasible approach to such ...
openaire +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Filters method in direct search optimization, new measures to admissibility
, 2011 Constrained nonlinear optimization problems are usually solved using penalty or barrier methods combined with unconstrained optimization methods. Another alternative used to solve constrained nonlinear optimization problems is the lters method ...
Correia, Aldina +3 more
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Direct Search Methods for Nonsmooth Problems using Global Optimization Techniques [PDF]
, 2010 This thesis considers the practical problem of constrained and unconstrained local optimization. This subject has been well studied when the objective function f is assumed to smooth. However, nonsmooth problems occur naturally and frequently in practice.
Robertson, Blair Lennon
core +1 more source