Results 51 to 60 of about 730,500 (301)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Smoothing and worst-case complexity for direct-search methods in nonsmooth optimization [PDF]
, 2013 In the context of the derivative-free optimization of a smooth objective function, it has been shown that the worst-case complexity of direct-search methods is of the same order as that of the steepest descent for derivative-based optimization; more ...
Vicente, Luís Nunes +1 more
core +1 more source
Zhongguo Jianchuan YanjiuObjectiveThis paper proposes a method for improving the efficiency and accuracy of finding the worst-case positions of wheel patch loads on deck grillage.
xiangyun LUO +3 more
doaj +1 more source
Efficient Local Search in Imaging Optimization Problems with a Hybrid Evolutionary Algorithm [PDF]
Journal of Systemics, Cybernetics and Informatics, 2005 The paper focuses on the efficiency of local search in a Hybrid evolutionary algorithm (HEA), with application to optimization problem frequently encountered in electronic imaging.
Igor Maslov
doaj
Population-based methods in the optimization of stand management
Silva Fennica, 2009 In Finland, the growth and yield models for tree stands are simulation programs that consist of several sub-models. These models are often non-smooth and non-differentiable.
Pukkala, Timo
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Directed search methods for surface structure determination by LEED [PDF]
Surface Science, 1990 Conventional surface crystallography by low-energy electron diffraction employs a trial-and-error search controlled at each step by a human being. This trial-and-error approach becomes very cumbersome and unreliable when it is applied to complex surfaces with a large number of unknown structural parameters.
Rous, P.J. +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Search for WIMPs at future μ + μ + colliders
Journal of High Energy PhysicsWeakly interacting massive particles (WIMPs) with electroweak charges, such as the wino and the Higgsino, stand out as natural candidates for dark matter in the universe. In this paper, we study the search for WIMPs at future multi-TeV μ + μ + colliders.
Hajime Fukuda +3 more
doaj +1 more source
Reinforcement learning in densely recurrent biological networks
iScienceSummary: Training highly recurrent networks is a technical challenge: gradient-based methods suffer from exploding or vanishing gradients, while purely evolutionary searches converge slowly.
Miles Walter Churchland +1 more
doaj +1 more source