Results 131 to 140 of about 112,764 (294)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Weed flora evolution in direct seeding under cover systems

, 2019
Prod 2019-109d EA GESTAD INRA DOCTNational audienceSince the beginning of agriculture, farmers have been working the soil to produce. With the apparition of mechanization (development of plow coupled to tractors in the early 20th century), this practice ...
Derrouch, Damien
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Productivity and global warming potential of direct seeding and transplanting in double-season rice of central China. [PDF]

Food Energy Secur, 2023
Xu L, Yuan S, Wang X, Yang G, Xiangcheng P, Yu X, Wang F, Huang J, Peng S.   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Direct seeded rice

, 2022
Anjani Kumar, Amaresh Kumar Nayak, Mehreteab Tesfai, Rahul Tripathi, Sangita Mohanty, Shyamaranjan Das Mohapatra, Kiran Mohapatra, Udaya Sekhar Nagothu   +7 more
openaire   +1 more source

A Straightforward Method to Prepare MOF-Based Membranes via Direct Seeding of MOF-Polymer Hybrid Nanoparticles. [PDF]

Membranes (Basel), 2023
Fang M, Drobek M, Cot D, Montoro C, Semsarilar M.   +4 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

The Recruitment of the Recalcitrant-Seeded Cryptocarya alba (Mol.) Looser, Established via Direct Seeding Is Mainly Affected by the Seed Source and Forest Cover. [PDF]

Plants (Basel), 2022
Magni CR, Saavedra N, Espinoza SE, Yáñez MA, Quiroz I, Faúndez Á, Grez I, Martinez-Herrera E.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Counting the cost of revegetation: is direct seeding cheaper than planting tube-stock?

, 2018
Direct seeding is often assumed to be cheaper than planting tube–stock, but limited data exist to compare the relative costs of the two techniques. At four riparian sites in Victoria, we assessed the number of plants established over time in the months ...
Dabal, R, Ede, F, Robertson, D, Greet, J
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