Results 71 to 80 of about 112,764 (294)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Adapting PILOTE model for water and yield management under direct seeding system: The case of corn and durum wheat in a Mediterranean context [PDF]

Crop models are useful tools for integrating knowledge of biophysical processes governing the plant-soil-atmosphere system. But few of them are easily usable for water and yield management especially under specific cropping systems such as direct seeding.
J.C. Mailhol, M.R. Khaledian, P. Ruelle, J.L. Rosique   +3 more
core  

Effects of different sowing techniques on productivity and botanical composition of grass/clover mixture

Mljekarstvo, 2004
In April 1999 field experiment was planted in Crkveni Bok near Sisak to evaluate the effect of different sowing techniques on productivity and botanical composition of grass/clover mixture.
Mladen Knežević, Josip Leto, Krešimir Bošnjak, Marina Vranić, Goran Perčulija, Hrvoje Kutnjak   +5 more
doaj  

Design of a Rice Rope Laying Machine for Direct Sowing

Engineering Transactions, 2017
The research and development of a rice rope laying machine (RRLM) provides new ideas for a design of a rice direct seeding machine, and solves existing problems encountered in direct seeding techniques currently in use.
Xiao-Lian LV, Xiao-Rong LV, Rong-Chao MA
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Direct seeding: An appropriate technology for the regeneration of degraded Aboriginal lands

, 1991
Vegetation management is not a new concept to many Aboriginal people. Traditional vegetation management practices such as patch burning required a thorough understanding of the ecology of vegetation communities, vegetation succession, and the associated ...
Penberthy, M.
core  

First direct seeding at 38 nm

, 2012
The sFLASH project at DESY is an experiment to study direct seeding using a source based on the high-harmonic generation (HHG) process. In contrast to SASE, a seeded FEL exhibits greatly improved longitudinal coherence and higher shot-to-shot stability ...
Hass, E.,, Drescher, M.,, Düsterer, S.,, Rehders, M.,, Ackermann, S.,, Tarkeshian, R.,, Lechner, C.,, Schroedter, L.,, Schlarb, H.,, Honkavaara, K.,, Curbis, F.,, Wieland, M.,, Miltchev, V.,, Azima, A.,, Laarmann, T.,, Rönsch-Schulenburg, J.,, Schreiber, S.,, Delsim-Hashemi, H.,, Tischer, M.,, Maltezopoulos, Th,, Rossbach, J.,, Bajt, S.,, Bödewadt, J.,, Ischebeck, R.,, Mittenzwey, M.,, Hipp, U.,, Dachraoui, H.,, Faatz, B.,, Wacker, V.,, Lund University.   +29 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Weed Management by Rice Straw Mulching in Direct Seeded Lowland Rice (Oryza sativa L.)

Tropical Agricultural Research, 2011
Direct seeding of rice (Oryza sativa L.) induces the production of greater grain yields in water deficit areas. However, weeds pose a serious threat to sustainability of yield of direct-seeded rice.
DAUD Devasinghe, KP Premarathne, UR Sangakkara   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source