Results 81 to 90 of about 5,999,057 (304)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

WTO direct action convergence, Seattle, WA (nov. 20-28), registration application [recto]

open access: yes, 1999
Alternate title: DAN registration. Affiliated web page url: www.agitprop.org/artandrevolution/wto. Library has 2 copies. Also sent out as document 6 of 19 in a Direct Action Network (DAN) organizing packet; these documents are contained in a 9 X 12 ...
Direct Action Network (DAN)
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

On the design and prospects of direct RNA sequencing [PDF]

open access: yesBriefings in Functional Genomics, 2017
Throughout the past nearly a decade, the application of high-throughput sequencing to RNA molecules in the form of RNA sequencing (RNA-seq) and its many variations has revolutionized transcriptomic studies by enabling researchers to take a simultaneously deep and truly global look into the transcriptome.
openaire   +2 more sources

NHS Direct

open access: yes, 2002
NHS Direct operates a 24-hour nurse advice and health information service, providing confidential information on: What to do if you or your family are feeling ill; Particular health conditions; Local healthcare services, such as doctors, dentists or late
NHS Direct
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Blind Demodulation of Chaotic Direct Sequence Spread Spectrum Signals Based on Particle Filters

open access: yesEntropy, 2013
Applying the particle filter (PF) technique, this paper proposes a PF-based algorithm to blindly demodulate the chaotic direct sequence spread spectrum (CDS-SS) signals under the colored or non-Gaussian noises condition.
Yimeng Zhang   +5 more
doaj   +1 more source

Directed degree sequences

open access: yes, 2011
Wir betrachten zwei Probleme der algorithmischen Graphentheorie und Netzwerkanalyse. Beim "Dag Realisationsproblem" sei eine endliche Sequenz S von Paaren natürlicher Zahlen gegeben. Gibt es einen Dag (ohne parallele Kanten und Schleifen) der S als Knotengradsequenz besitzt?
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Amplification and Direct Sequence Analysis of the 23S rRNA Gene from Thermophilic Bacteria

open access: yesBioTechniques, 2001
We present a simplified and fast method to obtain high-quality sequences directly from PCRs without the traditional gel purification. We also report on an improved method to obtain sequence-quality PCR products from microorganisms that are difficult to ...
Ashraf Ibrahim   +2 more
doaj   +1 more source

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