Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Dalam sistem komunikasi nirkabel, khususnya pada dunia komunikasi taktis atau militer, salah satu yang harus dihadapi adalah gangguan jamming.Salah satu sistem yang dapat mengatasi masalah tersebut adalah Direct Sequence Spread Spectrum (DSSS) dimana ...
Aditya Sukmana Putra +2 more
doaj
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
AN INTERFERENCE-IMMUNE COMMUNICATION SYSTEM FOR DIGITAL DATA TRANSMISSION BASED ON A MULTI-CHANNEL CORRELATOR Part 2. DEVELOPMENT OF A CORRELATION-TYPE TRANSCEIVER BASED ON A MULTI-CHANNEL CORRELATOR [PDF]
Subject and Purpose. The objective of Part 2 of the work is the development and experimental study of a multichannel correlator for creating a correlation-type transceiver based on software-defined radio (SDR) systems.
A. V. Varavin +7 more
doaj
Spread Spectrum Data Transmission System for User Unmanned Aerial Vehicles
In today’s world of unmanned aerial vehicle (UAV) telecommunications, data transmission is both important and delicate. Various organizations have used special techniques to ensure reliable transmission and stable communication. At this stage, we propose
Zellal Somia +3 more
doaj +1 more source
Publication in the conference proceedings of EUSIPCO, Florence, Italy ...
Jacek Leskow, Antonio Napolitano 0001
openaire +4 more sources
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source

