Results 61 to 70 of about 378,747 (352)
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Evaluation of shear mounted elastomeric damper [PDF]
, 1982 Viton-70 elastomeric shear mounted damper was built and tested on a T-55 power turbine spool in the rotor's high speed balancing rig. This application of a shear mounted elastomeric damper demonstrated for the first time, the feasibility of using ...
Walton, J., Zorzi, E.
core +1 more source
Large-scale direct shear test on the interface between geogrid and gravel-soil mixture
Shuiwen dizhi gongcheng dizhi, 2022 When geosynthetics are used in various types of reinforced soil projects, the main problems are the stability, safety and long-term service performance of the reinforced structures.
Jiaquan WANG +3 more
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Shear Strength Characteristics of Sand-Waste Material Mixture [PDF]
, 2009 This study investigates the shear strength characteristics of sand-waste material mixtures using direct shear test.
Abdul Ghani, Abdul Naser +2 more
core
Mohr-Coulomb Failure Condition and the Direct Shear Test Revisited
Acta Polytechnica, 2004 An alternative critical plane orientation is proposed in the Mohr-Coulomb failure criterion for soils with an extreme property. Parameter identification from the direct shear test is extended to incude the lateral normal stress.
P. Řeřicha
doaj
Shear Slip Instability Behavior of Rock Fractures under Prepeak Tiered Cyclic Shear Loading
Advances in Civil Engineering, 2020 In this paper, shear displacement properties of rock fractures were studied, and the energy evolution process was analyzed before sliding instability under complex shear loading paths. The artificial prefabrication method was used to simulate the natural
Minglei Zhai, Haibo Bai, Luyuan Wu
doaj +1 more source
Dynamic response of UHPFRCs in direct-shear tests
Procedia Structural Integrity, 2020 Abstract The comprehension of the phenomena caused by fast-transient-loading regimes on structures, such as impact or blast, plays a capital role in order to prevent catastrophic failures. In fact, very complex failure modes can occur at these regimes where compression, tensile and shear strengths are involved.
Matteo Dotta +3 more
openaire +2 more sources
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source