Results 41 to 50 of about 50,934 (264)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Direct simulation Monte Carlo: The quest for speed

AIP Conference Proceedings, 2014
In the 50 years since its invention, the acceptance and applicability of the DSMC method have increased significantly. Extensive verification and validation efforts have led to its greater acceptance, whereas the increase in computer speed has been the main factor behind its greater applicability.
Michael A. Gallis, John R. Torczynski, Steven J. Plimpton, Daniel J. Rader, Timothy Koehler   +4 more
openaire   +2 more sources

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Development of an adjoint flux calculation technique for exact perturbation theory in Monte Carlo transport

EPJ Nuclear Sciences & Technologies
A calculation technique computing the adjoint flux of perturbed system is developed for the exact perturbation theory in Monte Carlo transport. By using a correlated sampling and iterated fission probability methods together, the adjoint flux of ...
Jo Yunki, Lee Deokjung
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Response characteristics of MAPbBr3 direct conversion X-ray detectors based on measurements and Monte Carlo simulation

Heliyon, 2023
In recent years, higher requirements have been placed on the response characteristics of X-ray detectors in the field of medical diagnostic imaging. Due to this, high sensitivity, high attenuation coefficient and low cost detection materials need to be ...
Feng Qin, Rui Zhao, Wei Feng Zhu, Ning Qin Deng, Zhi Wei Jiao, Xian Qiang Tang, Jin Jie Wu   +6 more
doaj   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

Misadventures in Monte Carlo

Journal of Sports Analytics, 2019
Estimating probability is the very core of forecasting. Increasing computing power has enabled researchers to design highly intractable probability models, such that model results are identified through the Monte Carlo method of repeated stochastic ...
Richard Demsyn-Jones
doaj   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Novel Cartesian Implementation of the Direct Simulation Monte Carlo Method [PDF]

Journal of Thermophysics and Heat Transfer, 2011
A new Cartesian implementation of the direct simulation Monte Carlo (DSMC) method, named the hypersonic aerothermodynamics particle (HAP) code, is presented. This code is intended for rapid setup and simulation of rarefied flow problems, and as a framework for evaluating new physical models and numerical techniques.
Burt, Jonathan, Josyula, Eswar, Boyd, Iain D.   +2 more
openaire   +2 more sources