Results 221 to 230 of about 11,830,288 (332)

Tumor-directed evolution of VSVΔ51M produces novel viruses with enhanced antitumor efficacy. [PDF]

Front Mol Biosci
Albaradie OA, Moglan AM, Samman YM, Alsayegh FF, Alharbi HM, Almarghalani N, Alotaibi K, Jalal MM, Altayar MA, Saeedi NH, Niaz HA, Zakri S, Almuzaini A, Kaboha F, Alabbas SY, Albalawi YA, Alsofyani A, Pelin A, Alsayb MA, Damfo S, Mahmoud AB, Alkayyal AA.   +21 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Correction to 'Directed evolution of hyperactive integrases for site specific insertion of transgenes'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Training a phage to expand its host range: directed evolution against <i>Staphylococcus aureus</i> from diabetic foot infections. [PDF]

Antimicrob Agents Chemother
Plumet L, Magnan C, Morsli M, Richardoz M, Gaïa N, François P, Lavigne J-P, Costechareyre D, Molle V.   +8 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Directed evolution of APOX for proximity labeling using phenols with high redox potentials. [PDF]

Cell Chem Biol
Fang S, Acevedo LD, Solivais AJ, Zhou X, Patil SS, Delfosse ES, Yin H, Ziolkowski ZB, Frey BL, Chapman ER, Smith LM, Martell JD.   +11 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

De novo biosynthesis of alpinetin enhanced by directed evolution of 5-O-methyltransferase. [PDF]

Microb Cell Fact
Peng B, Wang Z, Zhang L, Groves MR, Haslinger K.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source