Results 91 to 100 of about 2,236,841 (295)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Host-directed therapies for infectious diseases : current status, recent progress, and future prospects

, 2016
Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage.
Rao, M., Rustomjee, R, Yeboah-Manu, Dorothy, Azhar, E., Rao, M,, Zumla, A, Kaufmann, Stefan H. E., Yeboah-Manu, D., Hoelscher, M., Vilaplana, Cris, Mwaba, P., Hoelscher, Michael, Wallis, RS, Mwaba, P, Chakaya, J, Kaufmann, SH, Host-Directed Therapies Network consortium,, Azhar, E, Ippolito, G, Maeurer, Markus, Wallis, Robert S., Zumla, A., Maeurer, M, Rao, Martin, Ippolito, Giuseppe, Hoelscher, M, Chakaya, Jeremiah, Rustomjee, Roxana, Chakaya, J., Ippolito, G., Rao, M, Zumla, Alimuddin, Kaufmann, SHE, Maeurer, M., Rustomjee, R., Vilaplana, C., Vilaplana, C, Kaufmann, S., Mwaba, Peter, Host-Directed Therapies Network consortium, Wallis, R., Azhar, Esam, Yeboah-Manu, D   +42 more
core   +1 more source

The bar-hinge motor: a synthetic protein design exploiting conformational switching to achieve directional motility

New Journal of Physics, 2019
One challenge to synthetic biology is to design functional machines from natural building blocks, from individual amino acids up to larger motifs such as the coiled coil.
Lara S R Small, Martin J Zuckermann, Richard B Sessions, Paul M G Curmi, Heiner Linke, Nancy R Forde, Elizabeth H C Bromley   +6 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm. [PDF]

Cells, 2023
Wang Z, Fang K, Wan Y, Yin Y, Li M, Xu K, Li T, Cao Y, Lv Y, Lu G, Liu H, Huang T.   +11 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Anisotropy of colloidal components propels field-activated stirrers and movers

Physical Review Research, 2020
Propulsion via cyclic moves presents a challenge to micro-objects in overdamped environments, where time reversibility may prevent directed motion. Most reported cyclic movers exploit anisotropic hydrodynamic drag with the surrounding medium to push or ...
Gabi Steinbach, Michael Schreiber, Dennis Nissen, Manfred Albrecht, Sibylle Gemming, Artur Erbe   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Directional motion asymmetry in infant VEPs — which direction?

Vision Research, 2001
Monocular viewing during early infancy reveals asymmetries in optokinetic nystagmus (OKN) and visual evoked potentials (VEPs). This study investigates the VEP asymmetry to see if it is consistent in direction with the OKN asymmetry. Steady-state VEPs were recorded from infants (5-21 weeks) viewing gratings that underwent successive displacements in the
Mason, A, Braddick, O, Wattam-Bell, J, Atkinson, J   +3 more
openaire   +2 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source