Results 111 to 120 of about 382,964 (309)

Optimization by Direct Search in Matrix Computations [PDF]

SIAM Journal on Matrix Analysis and Applications, 1993
Many questions about algorithms in matrix computations can be expressed in terms of the maximum value of some easily computable function \(f\). For many algorithms it is known that direct search is capable of revealing instability or proof performance.
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Search Intensity, Directed Search And The Wage Distribution [PDF]

We propose a search equilibrium model in which homogenous …rms post wages along with a vacancy to attract job-seekers, while homogenous unemployed workers invest in costly job-seeking.
André Zylberberg, Bruno Decreuse
core  

Adaptive Lévy processes and area-restricted search in human foraging [PDF]

, 2013
A considerable amount of research has claimed that animals’ foraging behaviors display movement lengths with power-law distributed tails, characteristic of Lévy flights and Lévy walks.
Wiener, J.M., Thomas T Hills, Jan M Wiener, Wiener Jan M., Kalff, C., Thomas T. Hills, Kalff, Christopher, Wiener, Jan M., Hills, T., Christopher Kalff, Hills Thomas T., Kalff Christopher, Jan M. Wiener, Hills, Thomas Trenholm   +13 more
core   +1 more source

The Local Galactic Transient Survey Applied to an Optical Search for Directed Intelligence

The Astrophysical Journal
We discuss our transient search for directed energy systems in local galaxies, with calculations indicating the ability of modest searches to detect optical Search for Extraterrestrial Intelligence sources in the closest galaxies. Our analysis follows P.
Alex Thomas, Natalie LeBaron, Luca Angeleri, Phillip Morgan, Varun Iyer, Prerana Kottapalli, Enda Mao, Samuel Whitebook, Jasper Webb, Dharv Patel, Rachel Darlinger, Kyle Lam, Kelvin Yip, Michael McDonald, Robby Odum, Cole Slenkovich, Yael Brynjegard-Bialik, Nicole Efstathiu, Joshua Perkins, Ryan Kuo, Audrey O’Malley, Alec Wang, Ben Fogiel, Sam Salters, Marlon Munoz, Natalie Kim, Lee Fowler, Ruiyang Wang, Philip Lubin   +28 more
doaj   +1 more source

Search on a Grid: Directed Consumer Search With Correlated Products

SSRN Electronic Journal
The consumer search literature mostly considers independently distributed products. In contrast, I study a model of directed search with infinitely many products whose valuations are correlated through shared attributes. I propose a tractable, systematic, history-dependent scoring system based on nests of correlated products that leverages the ...
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

'Residual' Wage Disparity in Directed Search Equilibrium [PDF]

We examine how much of the observed wage dispersion among similar workers can be explained as a consequence of a lack of coordination among employers.
Benoit Julien, John Kennes, Ian Paul King   +2 more
core  

Directed plateau search for MAX-k-SAT

, 2010
Local search algorithms for MAX-k-SAT must often explore large regions of mutually connected equal moves, or plateaus, typically by taking random walks through the region.
Howe, Adele, Whitley, L. Darrell, Sutton, Andrew M., Howe, Adele E., Whitley, L., Sutton, Andrew   +5 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source