Results 61 to 70 of about 22,888 (290)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sentiment Analysis of Meme Images Using Deep Neural Network Based on Keypoint Representation

Informatics
Meme image sentiment analysis is a task of examining public opinion based on meme images posted on social media. In various fields, stakeholders often need to quickly and accurately determine the sentiment of memes from large amounts of available data ...
Endah Asmawati, Ahmad Saikhu, Daniel O. Siahaan   +2 more
doaj   +1 more source

A fast and robust kernel optimization method for core–periphery detection in directed and weighted graphs

Applied Network Science, 2019
Many graph mining tasks can be viewed as classification problems on high dimensional data. Within this class we consider the issue of discovering core-periphery structure, which has wide applications in the economic and social sciences.
Francesco Tudisco, Desmond J. Higham
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Optimizing the Constrained Estimate of Random Walks

IEEE Access, 2018
We introduce the problem of optimizing the constrained estimate of random walks on the probability networks (which are formally defined as the weighted directed graphs in which the total outgoing weight of any node is at most 1).
Rong Zhou, Yong Zhang, Li Ning
doaj   +1 more source

Flow-augmentation I: Directed graphs

, 2022
We show a flow-augmentation algorithm in directed graphs: There exists a randomized polynomial-time algorithm that, given a directed graph $G$, two vertices $s,t \in V(G)$, and an integer $k$, adds (randomly) to $G$ a number of arcs such that for every ...
Wahlström, Magnus, Pilipczuk, Marcin, Kim, Eun Jung, Kratsch, Stefan   +3 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Brain network analysis : separating cost from topology using cost-integration [PDF]

, 2011
A statistically principled way of conducting brain network analysis is still lacking. Comparison of different populations of brain networks is hard because topology is inherently dependent on wiring cost, where cost is defined as the number of edges in
Ed T. Bullmore, Thomas E Nichols, Andrew Simmons, Ginestet, Cedric E., Bullmore, Ed T., Cedric E Ginestet, Nichols, Thomas E., Simmons Andrew, Cedric E. Ginestet, Bullmore, Edward T., Thomas E. Nichols, Nichols Thomas E., Ginestet Cedric E., Ed T Bullmore, Bullmore Ed T., Simmons, Andrew   +15 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source