Results 121 to 130 of about 336,346 (356)

Actio Directa as an Element of the Polish and European System of Protection of Victims of Traffic Accidents

open access: yesReview of European and Comparative Law
Liability insurance involves a direct claim by the injured party against the insurer (actio directa). In the case of compulsory motor insurance, it is guaranteed not only by the Polish Civil Code, but also by EU directives (currently Directive 2009/103 ...
Ewa Wójtowicz
doaj   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi   +26 more
wiley   +1 more source

Pitfalls in Implementing the EU Whistleblower Directive

open access: yesWroclaw Review of Law, Administration and Economics
In this paper, we focus on two conceptual problems associated with the EU Whistleblower Directive and point out issues that may undermine or even frustrate the successful implementation of the Directive in a national context.
Scheu Harald Christian
doaj   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

open access: yesMolecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam   +9 more
wiley   +1 more source

CRITICAL INFRASTRUCTURES PROTECTION A ROMANIAN PERSPECTIVE [PDF]

open access: yesAnnals: Series on engineering sciences (Academy of Romanian Scientists), 2010
In each EU Member States there are a certain number of critical infrastructures, the disruption or destruction of which is essential for the maintenance of vital societal functions, health, safety, security, economic or social well-being of people, and ...
Liviu MURESAN, Septimiu CACEU
doaj  

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

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