Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
REFORMING PUBLIC ADMINISTRATION IN THE CONTEXT OF THE EU SERVICES DIRECTIVE IMPLEMENTATION. A CASE STUDY ON THE BUSINESS REGISTRATION PROCESS IN ROMANIA [PDF]
Romania is currently facing a lot of challanges in the public administration (PA) field. In this context probably one of the most pressing factors is the European Union integration process. Thus, starting with 2007, when Romania joined the European Union,
Radu CONSTANTINESCU +5 more
core
Updates to the EU Directives on Professional Qualifications must align with global standards. [PDF]
PLOS Glob Public HealthBrigante L +6 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
The trade-induced effects of the Services Directive and the country of origin principle [PDF]
The proposed Services Directive by the European Commission could increase intra European trade in commercial services by 30 to 60 percent. This paper analyses the welfare effects of the trade growth using an applied general equilibrium model WorldScan ...
Arjan Lejour, Henk Kox, Roland de Bruijn
core
Can physics review catch prescription and PTV margin errors in fully automated radiotherapy plans? A hazard study. [PDF]
J Appl Clin Med PhysCourt LE +8 more
europepmc +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Regulating the financial analysis industry : Is the European Directive effective ? [PDF]
In the recent years, the US and the EC have witnessed the adoption of new regulations focused on financial analysts. This study investigates whether the European regulations, known as the Market Abuse Directive (MAD) changed the distribution of ...
Pascal Dumontier, M. Dubois
core
Orchestrating neuroimaging data processing using the 'Snakemake' workflow manager. [PDF]
Brain Struct FunctMannion DJ +3 more
europepmc +1 more source