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FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source

Pitfalls in Implementing the EU Whistleblower Directive

Wroclaw Review of Law, Administration and Economics
In this paper, we focus on two conceptual problems associated with the EU Whistleblower Directive and point out issues that may undermine or even frustrate the successful implementation of the Directive in a national context.
Scheu Harald Christian
doaj +1 more source

EU DIRECTIVES IN THE FIELD OF COPYRIGHT AND RELATED RIGHTS [PDF]

Challenges of the Knowledge Society, 2015
The aim of this article is to underline the evolution and the importance of the European Directives in the field of copyright and related rights, their contribution to the development of the law and the national implementation, namely their transposition
Ana-Maria MARINESCU
doaj

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source

THE OPTIONAL INSTRUMENT OF EUROPEAN CONTRACTS LAW [PDF]

Challenges of the Knowledge Society, 2011
The pragmatic approach of the European contracts lawissueimposes the conceptualization and the execution of a form to materialize it accordingly, thus as to meet the legal, economic, socialand political realitiesexisting at the level of the European ...
LUMINITA TULEASCA
doaj

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source

CRITICAL INFRASTRUCTURES PROTECTION. A ROMANIAN PERSPECTIVE (PART 2) [PDF]

Annals: Series on engineering sciences (Academy of Romanian Scientists), 2011
In each EU Member States there are a certain number of critical infrastructures, the disruption or destruction of which is essential for the maintenance of vital societal functions, health, safety, security, economic or social well-being of people, and ...
Liviu MURESAN, Septimiu CACEU
doaj

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source

J Replacement and Direct Roots of Direct Powers in Direct Products

Journal of Algebra, 1995
This article is a continuation of the author's previous works and dedicated to studying the replaceability properties of the direct product of groups. Here is the main definition. Let \(J\) be the infinite cyclic group and let \(\times^n C\) denote the direct product of \(n\) copies of the group \(C\). Consider the statements (1.1) \(J\times C\approx J\
openaire +2 more sources

paths and cycles
regulation
directed graphs digraphs , tournaments

speech act
3. good health
harmonization

humans