This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci+6 more
wiley +1 more source
Factors Associated with Family Caregivers' Intentions to Complete an Advance Directive for Individuals with Dementia: A Cross-Sectional Descriptive Study. [PDF]
Park H, Kang S, Kim Y.
europepmc +1 more source
Prediction of Directivity Patterns from Array Velocity Data and Comparison with Measured Patterns [PDF]
George J. Gruber, Gudin Tseo
openalex +1 more source
Landscape of BRAF transcript variants in human cancer
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda+5 more
wiley +1 more source
A Commentary on "Art Therapy Interventions for Syrian Child and Adolescent Refugees: Enhancing Mental Well-being and Resilience". [PDF]
Milev ST.
europepmc +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
Safety evaluation of the food enzyme glucose oxidase from the non-genetically modified <i>Penicillium rubens</i> strain PGO 19-162. [PDF]
EFSA Panel on Food Enzymes (FEZ)+19 more
europepmc +1 more source
3016) Directivities of Roof-ventilators as Noise Source(Scientific Basis of Planning Building)
Toshio Maeda+2 more
openalex +2 more sources
Sensitivity and directivity of piezoceramic tubes with capped or shielded ends [PDF]
W. James Trott
openalex +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source