Results 61 to 70 of about 336,346 (356)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
The EU Single-Use Plastics Directive and its impact on tobacco products: A policy analysis
Public Health and Toxicology, 2022 Single-use plastics (SUPs), which are used only once or briefly, have become a significant source of litter on European beaches and seas. The European Union (EU), approved the SUP Directive after acknowledging the significant harm that SUPs cause to the ...
Katerina Nikitara +4 more
doaj +1 more source
, 2016 The European Union (EU) Water Framework Directive (WFD) requires EU member states to produce and implement river basin management plans, which are to be designed and updated via participatory processes that inform, consult with, and actively involve all ...
Nicolas W. Jager +28 more
semanticscholar +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Directing citizens to create advance directives
Swiss Medical Weekly, 2018 This article describes the Swiss law on advance directives that was passed at the beginning of 2013 and led to more certainty about the legally binding character of such directives. However, for various reasons the drafting of advance directives is not yet widespread in Switzerland, and many resources might be put to better use if this became a common ...
Haesen, Sophie, Shaw, David
openaire +6 more sources
Direct WIMP detection in directional experiments [PDF]
Physical Review D, 2007 22 LaTex pages, 28 ...
J. D. Vergados +2 more
openaire +3 more sources
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Acta Universitatis Lodziensis Folia IuridicaThe objective of this paper is to analyse the mechanisms established by the Directive 2022/2041 for the purpose of determining adequate and fair minimum wages and promoting collective bargaining.
Błażej Mądrzycki, Łukasz Pisarczyk
doaj +1 more source
CRITICAL INFRASTRUCTURES PROTECTION A ROMANIAN PERSPECTIVE (PART 1) [PDF]
Annals: Series on engineering sciences (Academy of Romanian Scientists), 2011 In each EU Member States there are a certain number of critical infrastructures, the disruption or destruction of which is essential for the maintenance of vital societal functions, health, safety, security, economic or social well-being of people, and ...
Liviu MURESAN, Septimiu CACEU
doaj