Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Phenotypic and genetic analysis of energy partitioning and feed efficiency in Atlantic salmon. [PDF]
Sonesson AK +3 more
europepmc +1 more source
Plasma Functional Proteins and Peptides: A Sustainable Nutritional Alternative to Support Piglet Performance and Health. [PDF]
Polo J +4 more
europepmc +1 more source
Safety evaluation of the food enzyme endo-1,4-β-xylanase from the non-genetically modified <i>Trichoderma citrinoviride</i> strain TCLSC. [PDF]
EFSA Panel on Food Enzymes (FEZ) +17 more
europepmc +1 more source
The Current Landscape of Ophthalmology Training in Europe. [PDF]
Sidiropoulou M.
europepmc +1 more source
Safety evaluation of the food enzyme containing metalloendopeptidase and leucyl aminopeptidase activities from the non-genetically modified <i>Aspergillus oryzae</i> strain HBI-POP01. [PDF]
EFSA Panel on Food Enzymes (FEZ) +19 more
europepmc +1 more source
An inpatient Serious Illness Care Program for older patients with hematologic malignancies: a single-arm pilot study. [PDF]
LoCastro M +17 more
europepmc +1 more source

