Results 101 to 110 of about 2,997,836 (405)

Diagnostic exome sequencing in persons with severe intellectual disability.

New England Journal of Medicine, 2012
BACKGROUND The causes of intellectual disability remain largely unknown because of extensive clinical and genetic heterogeneity. METHODS We evaluated patients with intellectual disability to exclude known causes of the disorder.
J. de Ligt, M. Willemsen, B. V. van Bon, T. Kleefstra, H. Yntema, Thessa Kroes, A. V. Vulto-van Silfhout, D. Koolen, P. D. de Vries, C. Gilissen, Marisol Del Rosario, A. Hoischen, H. Scheffer, B. D. de Vries, H. Brunner, J. Veltman, L. Vissers   +16 more
semanticscholar   +1 more source

Factors for Rituximab Refractoriness in AQP4‐IgG+ NMOSD: A Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin‐4 antibodies (AQP4‐IgG). Rituximab, a CD20+ B‐cell depleting monoclonal antibody, is widely used as first‐line therapy.
Mariano Marrodan, María A. Piedrabuena, María A. Zarate, Sofía Rodríguez Murúa, Ezequiel I. Surace, Mauricio F. Farez, Marcela P. Fiol, María C. Ysrraelit, Jorge Correale   +8 more
wiley   +1 more source

Entering the World of Work: What Youth With Mental Health Needs Should Know About Accommodations [PDF]

, 2007
[Excerpt] Starting a job can be difficult for any young person. If you happen to have a hidden disability, such as a mental health impairment, a new workplace can be overwhelming. If you have ever felt this way, you are not alone.
Office of Disability Employment Policy
core   +1 more source

Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability.

New England Journal of Medicine, 1995
BACKGROUND Functional assessment is an important part of the evaluation of elderly persons. We conducted this study to determine whether objective measures of physical function can predict subsequent disability in older persons.
J. Guralnik, L. Ferrucci, E. Simonsick, M. Salive, R. Wallace   +4 more
semanticscholar   +1 more source

Influence of Dystrophin Isoform Deficiency on Motor Development in Duchenne Muscular Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In Duchenne muscular dystrophy (DMD), lack of the shorter dystrophin isoforms Dp140 and Dp71 is associated with increased central nervous system (CNS) involvement. We aimed to investigate how CNS involvement affects motor development in young DMD boys.
Mary Chesshyre, Deborah Ridout, Georgia Stimpson, Laurent Servais, Giovanni Baranello, Adnan Manzur, UK NorthStar Clinical Network, M. Scoto, A. Sarkozy, P. Munot, S. Robb, E. Chan, V. Robinson, W. Girshab, V. Crook, E. Milev, L. Abbott, A. Wolfe, E. O’Reilly, J. Watts‐Whent, N. Burnett, R. Thomas, R. Terespolsky, O. Martinaeu, J. Longatto, V. Straub, C. Bettolo, M. Guglieri, J. Diaz‐Manera, G. Tasca, M. Elseed, R. Muni‐Lofra, M. James, D. Moat, J. Sodhi, K. Wong, E. Robinson, E. Groves, R. Rabb, D. Parasuraman, H. McMurchie, H. Chase, Tracey Willis, C. Rylance, N. Birchall, E. Wright, A. Childs, K. Pysden, C. Martos, D. Roberts, L. Pallant, S. Walker, A. Henderson, R. Madhu, R. Karuvattil, Y. Balla, S. Gregson, S. Clark, E. Wraige, H. Jungbluth, V. Gowda, M. Vanegas, J. Sheehan, A. Schofield, C. Smith, I. Hughes, E. Whitehouse, S. Warner, E. Reading, N. Emery, J. Moustoukas, K. Strachan, M. Ong, M. Atherton, N. Mills, S. Sanchez Marco, A. Saxena, K. Skone, J. TeWaterNaude, H. Davis, C. Wood, A. Majumdar, A. Murugan, I. Guarino, R. Tomlinson, H. Jarvis, L. Wills, C. Frimpong, J. Watson, G. Cobb, G. Robertson, P. Brink, J. Burslem, C. Adams, J. Wong, S. Joseph, I. Horrocks, J. Dunne, M. DiMarco, S. Brown, S. McKenzie, K. Torne, R. Mohamed, V. Velmurugan, M. Prasad, S. Sedehizadeh, A. Schugal, R. Keetley, S. Williamson, K. Payne, E. Dowling, P. Fenty, C. de Goede, A. Parkes, K. Baxter, M. Illingworth, N. Bhangu, S. Geary, J. Palmer, K. Shill, S. Tirupathi, A. Shah, D. O’Donogue, J. McVeigh, J. McFetridge, G. Nicfhirleinn, H. Beattie, T. Leyland, K. Stevenson, N. Hussain, D. Baskaran, Z. Lambat, R. Sullivan, L. Locke, G. Ambegaonkar, D. Krishnakumar, J. Taylor, J. Moores, E. Stephen, J. Tewnion, S. Ramdas, M. Sa, A. Skippen, M. Khries, C. Lilien, H. Ramjattan, F. Taylor, H. English, K. Stewart, F. Flint, E. Bartram, R. Noble, Francesco Muntoni   +152 more
wiley   +1 more source

Using knowledge management tools in the Saudi National Mental Health Survey helpdesk: pre and post study

International Journal of Mental Health Systems, 2019
Background With the growth of information technology, there is a need for the evaluation of cost-effective means of monitoring and support of field workers involved in large epidemiological surveys.
Maggie Aradati, Lisa Bilal, Mohammad Talal Naseem, Sanaa Hyder, Abdulhameed Al‐Habeeb, Abdullah Al-Subaie, Mona Shahab, Bilal Sohail, Mansoor Baig, Abdulrahman Binmuammar, Yasmin Altwaijri   +10 more
doaj   +1 more source

Interviewing Essentials: Strategies For Creating A Positive Impression [PDF]

, 2005
[Excerpt] Congratulations! If you have been called for a job interview, the employer must have been impressed with your resume. You successfully passed the first critical step in the job-seeking process.
Office of Disability Employment Policy
core   +1 more source

Genetic Profile and Symptom Pattern Explain Variability of Deep Brain Stimulation Effect in Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Bilateral globus pallidus pars interna deep brain stimulation (GPi‐DBS) is a recognized and effective treatment option for drug‐resistant dystonia patients. However, the clinical GPi‐DBS outcomes vary significantly. Herein, we explored the pre‐implant factors affecting GPi‐DBS effectiveness.
Mahboubeh Ahmadipour, Luigi M. Romito, Antonio E. Elia, Nico Golfré Andreasi, Roberto Eleopra, Alberto Mazzoni, Fabiana Colucci   +6 more
wiley   +1 more source

Active Seizures Predict Worse Instrumental Activities of Daily Living in Individuals With Normal Cognition and Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Cognitive disorders are common in older persons with seizures (PWS). Cognitive disorders are often associated with impaired Instrumental Activities of Daily Living (IADLs). However, the effects of seizures on IADLs remain unexplored.
Ifrah Zawar, Jaideep Kapur, Meghan M. Mattos, Carol Manning, Syeda Amrah Hashmi, Mark Quigg   +5 more
wiley   +1 more source

A systematic review of strategies to increase access to health services among children in low and middle income countries

BMC Health Services Research, 2017
Background Universal Health Coverage is widely endorsed as the pivotal goal in global health, however substantial barriers to accessing health services for children in low and middle-income countries (LMIC) exist.
Tess Bright, Lambert Felix, Hannah Kuper, Sarah Polack   +3 more
doaj   +1 more source