Results 251 to 260 of about 2,978,128 (338)

Guesstimation of Molecular Ensemble Electrostatics Properties Through SCERPA‐DFT Calculation: Molecular Field‐Coupled Nanocomputing as a Case Study

open access: yesAdvanced Theory and Simulations, EarlyView.
This work presents a framework combining the Self‐Consistent Electrostatic Potential Algorithm (SCERPA) and Density‐Functional Theory calculations to efficiently evaluate the electronic properties of molecular ensembles. The approach achieves ab initio‐comparable precision while significantly reducing computation time and provides the first DFT ...
Yuri Ardesi   +4 more
wiley   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

open access: yesAdvanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi   +16 more
wiley   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

open access: yesAdvanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang   +15 more
wiley   +1 more source

Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis. [PDF]

open access: yesPLoS Med
Atkinson JA   +6 more
europepmc   +1 more source

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