Results 81 to 90 of about 1,141,114 (246)

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

The legality of weight discrimination in Canada: an environmental scan of case law and the limits of Canadian legislation

International Journal for Equity in Health
Weight stigma negatively impacts people with higher weights across the lifespan as well as social contexts and can lead to weight discrimination. As weight is not a protected identity in Canadian human rights legislation, it is important to better ...
Sarah Nutter, Rachel Waugh, Erin McEachran, Ashley Toor, Jacob Shelley, Angela S. Alberga, Mary Forhan, Sara FL Kirk, Taniya S. Nagpal, Ian Patton, Ximena Ramos Salas, Shelly Russell-Mayhew   +11 more
doaj   +1 more source

"Just How Much Diversity Will the Law Permit?": The Americans with Disabilities Act, Diversity and Disability in Higher Education

Disability Studies Quarterly, 2015
Civil rights laws including the Civil Rights Act of 1964, Title IX of 1972, Section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Act of 1990 worked to protect classes and individuals for whom discrimination had been ...
Lauren Shallish
doaj   +1 more source

Osseoperceptive EMG Feedback Improves Grasp Force Control in Myoelectric Prosthetic Hands

Advanced Science, EarlyView.
Osseoperception is explored as a non‐invasive pathway for delivering sensory feedback in myoelectric prosthetic control. By encoding the user's electromyographic (EMG) signal through bone‐conducted stimulation, this approach enables predictive grasp force regulation.
Cristian Felipe Blanco‐Diaz, Strahinja Dosen, Leonardo Cappello   +2 more
wiley   +1 more source

JOB DISCRIMINATION AGAINST INDIVIDUALS WITH DISABILITIES

Humanities and Social Sciences
The purpose of this study is to identify the relationship between holding a disability certificate and job discrimination. The motivation for conducting this research is to identify a research gap relating to the insufficient recognition of the issue of ...
Elżbieta STOLARSKA-SZELĄG, Katarzyna KRÓL   +1 more
doaj   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Policies to change attitudes to people with disabilities

Scandinavian Journal of Disability Research, 2017
Negative attitudes are a major barrier to the equality of people with disabilities. Governments and other organizations have implemented numerous programmes to change attitudes towards people with disabilities.
Karen R. Fisher, Christiane Purcal
doaj   +1 more source

Listening for policy change: how the voices of disabled people shaped Australia’s National Disability Insurance Scheme [PDF]

, 2014
: Voice has become an important yet ambivalent tool for the recognition of disability. The transformative potential of voice is dependent on a political commitment to listening to disabled people. To focus on listening redirects accountability for social
Thill, Cate, Cate Thill
core   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

Hátrányos megkülönböztetés a fogyatékossággal élő tanulók oktatásában [PDF]

PedActa, 2017
Although every democratic country prohibits discrimination in its legislation, discrimination is present on all levels of public, social, cultural, economic and private life. Education is no exception, discrimination is present, especially against pupils
Jánosi Dalma
doaj