Results 61 to 70 of about 1,654,065 (252)

Enjeu éthique d’une ontologie de la différence. La situation de handicap comme question sociale et politique

open access: yesFranciscanum, 2017
What is there to see in others? How to avoid sorters trends that lead us to include a fixed or negative identity; a fortiori when it is a disability? How to articulate, from an ethical point of view, the necessary diagnostic of others’ suffering with ...
Fred Poché
doaj   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

open access: yesAdvanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu   +13 more
wiley   +1 more source

Other title: Kansas Department for Aging and Disability Services Update; Other title: Update

open access: yes, 2016
application/pdf; "August 5, 2016."; "Reporting Date 06/30/2016."; Presentation before the Kansas Legislature, Robert G. Bethell Joint Committee on Home and Community Based Services and KanCare Oversight, presented by the Kansas ...
Kansas. Department for Aging and Disability Services.
core   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

open access: yesAdvanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu   +7 more
wiley   +1 more source

Other title: Client Assessment Referral and Evaluation Level II Instruction Manual : Intellectual/Developmental Disability Other title: Level II Instruction Manual : Intellectual/Developmental Disability Other title: Intellectual/Developmental Disability

open access: yes, 2015
"Effective July 1, 2015.""Instructions for CARE Level II Preadmission Screening for Intellectual/Developmental Disability and Other Related ...
Kansas. Department for Aging and Disability Services. CARE Program.
core  

Other title: Kansas Department for Aging and Disability Services Update; Other title: Update

open access: yes, 2017
"April 19, 2017."Presentation before the Kansas Legislature, Robert G. Bethell Joint Committee on Home and Community Based Services and KanCare Oversight, presented by the Kansas Department for Aging and Disability Services.Presentation giving statistics
Kansas. Department for Aging and Disability Services.
core   +1 more source

The Role of the Evaluation in the Theoretical Focuses on the Social Politics: the Case of Disability

open access: yesSantiago, 2015
The social politics  constitute a space of interesting diverse and contradictory analysis inside the different social contexts. Their reach should guide us toward the different sectors of the society in the search of its social well-being.
MSc. Osmanys Soler-Nariño   +1 more
doaj  

Chinese Special Needs Adoption, Demand, and the Global Politics of Disability

open access: yesDisability Studies Quarterly, 2019
This article explores three related phenomena: first, the abandonment and institutionalization of children with disabilities in China that increased disproportionately in the 2000s; second, the important relationships between such abandonments, culture ...
Erin Raffety
doaj   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

open access: yesAdvanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang   +13 more
wiley   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li   +8 more
wiley   +1 more source

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