Results 41 to 50 of about 15,544,582 (274)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Disability, Happiness and the Welfare State
This book looks at disability as an evolving social phenomenon. Disability is created through the interaction between persons with impairments and their environment. Exploring these experiences of persons with disabilities and discussing universality and
core +2 more sources
Disability Studies Quarterly, 2014 This is an introduction and has no abstract.
Michelle Jarman, Alison Kafer
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Self-directed disability support: building people’s capacity through peer support and action research [PDF]
, 2014 How are people with disability experiencing and managing the transition towards self directed support and preparing for the NDIS? In this project, small groups of people with disability around Australia met over 6 months to talk about their disability ...
Fisher, KR ; https://orcid.org/ +13 more
core +2 more sources
ChildrenThe journal retracts the article titled “Universal Design for Learning for Children with ADHD” [...]
Alessandro Frolli +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Scandinavian Journal of Occupational Therapy, 2018 Background: Life quality has become a widely used concept within rehabilitation and occupational therapy practice. Aim: This study explored child and parent perspectives of life quality of children with physical impairments compared with a group of non ...
Linda Björk Ólafsdóttir +3 more
doaj +1 more source
Disability inclusion in African health systems’ responses during COVID-19: A scoping review
African Journal of Disability, 2023 Background: People with disabilities often experience poorer access to healthcare because of multiple barriers even in non-crisis times, especially more so in low- and middle-income countries.
Madri Engelbrecht +4 more
doaj +1 more source