Results 51 to 60 of about 1,577,622 (295)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Scandinavian Journal of Occupational Therapy, 2018 Background: Life quality has become a widely used concept within rehabilitation and occupational therapy practice. Aim: This study explored child and parent perspectives of life quality of children with physical impairments compared with a group of non ...
Linda Björk Ólafsdóttir +3 more
doaj +1 more source
Disability Studies: What’s the Point? [PDF]
, 2003 [Excerpt] While the content of these courses had much to offer in terms of furthering our understanding of the experience of ‘chronic illness’ and the ensuing economic and social outcomes in terms of daily living for disabled people and their families ...
Barnes, Colin
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Tragic but brave or just crips with chips? Songs and their lyrics in the Disability Arts Movement in Britain [PDF]
, 2009 Disability culture is a site within which social and positional identities are struggled for and dominant discourses rejected; in which mainstream representations of people with impairments – as victims of personal tragedy – are held to the light and ...
Barnes +27 more
core +2 more sources
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
GMS Journal for Medical Education, 2020 The “Disability and Diversity Studies“ (DDS) are research fields which, similar to social work, deal with social inclusion and exclusion processes. Dimensions of disability and diversity can lead to disadvantages and inequalities in the individual life ...
Dungs, Susanne +2 more
doaj +1 more source
Disability unplugged: What really matters to people with disabilities?
African Journal of Disability, 2022 No abstract available.
Chioma Ohajunwa +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Accessibility of Dutch Public Space: Regulations and Local Actions by Pedestrians with Disabilities
LawsThis article examines the accessibility of public space for individuals with disabilities in the Netherlands, as well as the relevant legal frameworks intended to promote accessibility.
Dick Houtzager, Edwin Luitzen De Vos
doaj +1 more source