Results 151 to 160 of about 225,270 (313)
Advanced Science, EarlyView.SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio +6 more
wiley +1 more source
Vocational Cyber-education Needs Analysis for the Disabled Workforce [PDF]
, 2003 The researchers conducted a survey research pursuing for understanding of vocational training needs for the disabled workforce in Korea. The 284 samples for the study was randomly selected out of the 95,487 population registered to the database of the ...
조일현
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Advanced Science, EarlyView.This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei +18 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu +17 more
wiley +1 more source
A study of the nature and determinants of non-disabled persons attitudes towards persons with physical disabilities and disabled persons attitudes towards their disabilities and self-acceptance as measured by the attitudes toward disabled persons scale [PDF]
, 1975 Includes bibliographical references.The research objectives of this study were to test a number of hypothesized relationships between the dependent variables, that is, attitudes towards disabled persons and attitude intensity, and certain independent ...
Riese, Edward David
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Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai +11 more
wiley +1 more source
Liberating the disabled identity: a coalition of subjugated knowledges [PDF]
, 2004 My thesis explores the notion, originally developed by sociologists such as Goffman and Charmaz, that a person's identity undergoes a difficult and painful metamorphosis in response to the effects of serious long-term impairment or chronic illness.
Galvin, Rose
core +1 more source
Advanced Electronic Materials, EarlyView.A diagnostic method for reconfigurable intelligent surfaces (RIS) based on non‐uniform space‐time‐coding modulation is presented. Fault localization is achieved via amplitude‐only spectral measurements, eliminating the need for complex signal processing. A one‐to‐one mapping between harmonic components and RIS elements enables accurate detection.
Xiao Qing Chen +8 more
wiley +1 more source
Advanced Electronic Materials, EarlyView.In dynamic driving scenarios, the proposed approach ensures only temporally aligned sensor inputs to make driving decisions, preventing false activations. By enabling selective hardware‐level learning, it achieves fast, reliable responses under noisy conditions.
Kapil Bhardwaj +4 more
wiley +1 more source
Volunteering, Income Support Programs and Disabled Persons [PDF]
We study the propensity of disabled persons to engage in volunteer activity with the Participation and Activity Limitation Survey (PALS) -- a unique Canadian dataset which provides extensive information on disabled persons as well as volunteering ...
Gunderson, Morley +2 more
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