Results 131 to 140 of about 848,368 (315)
Advanced Science, EarlyView.ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao +12 more
wiley +1 more source
Technologies for the Disabled [PDF]
, 2017 Nowadays computers have taken the dominant role in our society.Most jobs now require access to computers and the Internet. But what happens if a person is blind, deaf or physically disabled?
Grechikhina, Julia +2 more
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PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility
Advanced Science, EarlyView.PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao +7 more
wiley +1 more source
Caring for Caregivers in Retirement: Social Security Works for Direct Care Workers [PDF]
, 2012 Social Security provides the basic foundation for the economic security of retired workers, workers who become disabled before retiring, and the children and spouses of workers who die or become disabled.
Shawn Fremstad
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Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
SOME REFLECTIONS ON NEW YORK CITY\u27S DISABILITY LAW [PDF]
, 1989 The article provides a broad overview of general disability law, and the distinctive features of New York City\u27s disability law. The author introduces American human rights law as distinct in that it does not purport to advance the needs of the ...
Hammel, Robert
core +1 more source
Advanced Science, EarlyView.An on‐demand ultra‐reconfigurable intelligent vision system with hierarchical reconfigurability from device to system levels is demonstrated. Through co‐design of a multi‐paradigm device, reconfigurable circuits, and adaptive system architecture/algorithms, the system enables seamless switching among spiking, non‐spiking, neuromorphic imaging (NI), and
Biyi Jiang +7 more
wiley +1 more source
Advanced Science, EarlyView.Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian +13 more
wiley +1 more source
Advanced Science, EarlyView.A probabilistic framework based on random time‐space coding metasurfaces enables control of the spatial distribution of electromagnetic fields temporal statistics. By tailoring the marginal and joint distributions of random codes, electromagnetic fields with desired mean and variance patterns are realized, enabling simultaneous transmission and jamming.
Jia Cheng Li +3 more
wiley +1 more source
Disability Studies: What’s the Point? [PDF]
, 2003 [Excerpt] While the content of these courses had much to offer in terms of furthering our understanding of the experience of ‘chronic illness’ and the ensuing economic and social outcomes in terms of daily living for disabled people and their families ...
Barnes, Colin
core +1 more source