Results 131 to 140 of about 225,270 (313)
Advanced Science, EarlyView.This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng +13 more
wiley +1 more source
Exploring disabled learners’ experiences of e-learning: LEXDIS Project Report [PDF]
, 2008 The LEXDIS Project was funded under phase two of the JISC e-learning pedagogy programme. The overarching aim of the study was to explore the e-learning experiences of disabled learners within the University of Southampton in order to increase ...
Draffan, E.A, Wald, Mike, Seale, Jane
core
Accessible Environment for Young People with Disabilities in St Petersburg: Sociological Analysis
ДискурсIntroduction. The article is devoted to the opportunities and barriers of the environment. It is proposed to look at the creation of an “accessible environment” not only as the elimination of physical barriers, but also from the point of view of its ...
O. A. Novozhilova
doaj +1 more source
Advanced Science, EarlyView.A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee +6 more
wiley +1 more source
Advanced Science, EarlyView.Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu +10 more
wiley +1 more source
Occupational therapists : empowerors or oppressors? : a study of occupational therapy students' attitudes towards disabled people [PDF]
The aim of the research was to investigate the concepts of, and attitudes towards, people with physical disabilities held by occupational therapy (OT) students, so that a theory of professional attitudes and professional action could be developed. The
Taylor, M. Clare
core
Advanced Science, EarlyView.Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source
The Impact of Short Breaks on Families with a Disabled Child: Report One of the Quantitative Phase [PDF]
, 2010 This document reports on a cross-sectional sample of families with a disabled child using short breaks in England; it describes the characteristics of children and families using short breaks, the nature and quantity of the short breaks they are using ...
Wells, Emma +6 more
core
Ethical Precision in Nanoscale Brain Interfacing
Advanced Science, EarlyView.As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley +1 more source