Results 91 to 100 of about 14,134 (184)

Multi‐Omics Analyses Reveal the Red and Far‐Red Light Combination Enhancing Heterologous Protein and Metabolite Production in Nicotiana benthamiana

Plant, Cell &Environment, Volume 49, Issue 10, Page 7435-7448, October 2026.
ABSTRACT Transient expression of exogenous protein in Nicotiana benthamiana leaves via agroinfiltration offers a rapid and efficient platform for functional gene discovery and heterologous production of valuable eukaryotic proteins and metabolites. Though light quality is an important factor for plant photomorphogenesis, its impact on the efficiency of
Yating Zhang, Fengjiao Wang, Ran Du, Tao Li, Shaoqun Zhou, Jianbin Yan, Wei Li   +6 more
wiley   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, Volume 13, Issue 53, 24 September 2026.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source

Hawaiʻi Disarmament Newsletter 1983 Vol. 2 No. 2

, 1983
This newsletter covers the Disarmament Film Festival, 1983 Europeace tour, Legislative Alert on the Final Decision on MX Due Soon, Nuclear Free and Independent Pacific Conference, Japanese American Survivors of the Atomic ...
American Friends Service Committee-Hawaiʻi
core  

State-of-the-Art Report [Elektronisk resurs] : Prepared by Working Group 4: Technical nuclear non-proliferation and safeguards under the Alva Myrdal Centre for nuclear disarmament

, 2022
The Alva Myrdal Centre for nuclear disarmament (AMC) was established in 2021. AMC consists of six working Groups, and one of them - Working Group 4 - is called Technical nuclear non-proliferation and safeguards.
Österlund, Michael,, Kelley, Robert E.,, Mishra, Vaibhav,, Gustavsson, Cecilia,, Grape, Sophie,, Andersson, Peter,, Göök, Alf,, Branger, Erik,, Fedchenko, Vitaly,, Preston, Markus,   +9 more
core  

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

Hawaiʻi Disarmament Newsletter 1983 Vol. 2 No. 2

, 1984
This newsletter covers the Disarmament Film Festival, 1983 Europeace tour, Legislative Alert on the Final Decision on MX Due Soon, Nuclear Free and Independent Pacific Conference, Japanese American Survivors of the Atomic ...
American Friends Service Committee-Hawaiʻi
core  

India’s Disarmament Initiative 1988: Continuing Relevance, Valid Pointers for an NWFW

Cadmus, 2012
The run up to the NPT Review Conference in 2010 brought nuclear disarmament into focus. Transitory though this trend turned out to be, it nevertheless became a trigger for India to re-examine its own position on disarmament. In order to take a considered
Manpreet Sethi
doaj  

Dams, hegemony and beyond: China’s hydro-stability in the evolving world order

Discover Global Society
Water has remained a source of contentious and cooperative politics among states since the Sumerian civilization. The field of hydro-politics, since its emergence in the 1990s, had taken note of dams as both a source of conflict between riparian ...
Porkkodi Ganeshpandian
doaj   +1 more source

No First Use and Credible Deterrence

Journal for Peace and Nuclear Disarmament, 2018
Despite progress in reducing the number of nuclear weapons in the largest arsenals, a number of states are now looking to increase their reliance on nuclear weapons not only for deterrence, but also for coercion or war fighting.
Steve Fetter, Jon Wolfsthal
doaj   +1 more source