Results 191 to 200 of about 1,113,893 (306)

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Letter to the Editor Regarding “Devastating ‘DANA’ Floods in Valencia: Insights on Resilience, Challenges, and Strategies Addressing Future Disasters”

Public Health Reviews
María García-García, Alicia Castro-Fernández, Amparo Ortega-Yago, Alessandro Thione, Víctor García-Bustos, Víctor García-Bustos   +5 more
doaj   +1 more source

Mine Waste Disasters on the Zambian Copperbelt: Regulatory and Community Concerns. [PDF]

Environ Manage
Mukumba CP, Sishekanu M, Marais L.
europepmc   +1 more source

Practical Lithium–Sulfur Batteries: An Integrated Design Roadmap from High‐Loading Cathodes to High‐Energy Pouch Cells

Advanced Science, EarlyView.
This review presents an integrated design roadmap for practical lithium–sulfur batteries, moving beyond isolated material breakthroughs to the synergistic combination of three interdependent frontiers: Scale‐Up, Electrolyte‐Cathode Synergy, and AI/ML Data‐Driven Design.
Shihzad Shakil, Fan Wang, Lejun Fu, Yuye Huang, Hanhui Lei, Jiarui Huang, Terence Xiaoteng Liu   +6 more
wiley   +1 more source

Perceived Stress and Compassion Satisfaction Among Nurses: A Mediation Model of Perceived Disaster Preparedness. [PDF]

J Nurs Res
Chiang KJ, Chang LF, Chou LJ, Huang LC, Kao YL, Lin C, Chen YH, Hung AH, Pan HH.   +8 more
europepmc   +1 more source

Rejuvenated Amorphous Alloys: Processing Methods, Microstructures and Mechanical Properties

Advanced Science, EarlyView.
Three rejuvenation methods – mechanical and thermal rejuvenation, and other rejuvenation routes such as ultrasonic processing – can be used to modify structures of glassy alloys, especially atomic clusters, and therefore enhances plasticity and activates work‐hardening behaviors.
Can Yang, Yu Chen, Chunguang Tang, Si Lan, Jun Tan, Heng Ye, Hua Chen, Zhifu Yao, Jürgen Eckert, Dongxian Zhang, Jian‐Zhong Jiang   +10 more
wiley   +1 more source

Long-term physical and mental health effects of unresolved disaster-related bereavement: evidence from an 8-year propensity score-matched cohort study. [PDF]

Eur J Psychotraumatol
Park EJ, Han JW, Noh M, Jeon S, Park B, Choi Y, Kim HS, Jung HS, Na KS, Lee WY.   +9 more
europepmc   +1 more source

Natural disasters [PDF]

BMJ, 2005
openaire   +2 more sources

High Fracture Toughness of 1D Copper‐Based MOP Electrode Enables Fast‐Charging Lithium‐Ion Batteries

Advanced Science, EarlyView.
Traditional electrode materials suffer from particle cracking and rapid capacity fade during fast charging, largely originating from their low fracture toughness. This work introduces a one‐dimensional Cu‐based metal–organic polymer, in which strong π‐d conjugation and π–π stacking endow the framework with high fracture toughness, simultaneously ...
Mingli Li, Zhenzhen Wu, Pan Yang, Di Zhao, Mengyang Dong, Muhammad Tayyab Ahsan, Lei Zhang, Shanqing Zhang, Yun Wang   +8 more
wiley   +1 more source