Results 11 to 20 of about 271,999 (308)
Government spending shocks and the multiplier: New evidence from the U.S. based on natural disasters [PDF]
, 2012 The literature on estimating macroeconomic effects of fiscal policy requires suitable instruments to identify exogenous and unanticipated spending shocks. So far, the instrument of choice has been military build-ups.
Ghosh, S, Yang, W, Fidrmuc, J
core +6 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Discover GeoscienceAccurate flood susceptibility modeling is critical for effective disaster risk management, particularly in rapidly urbanizing regions exposed to extreme precipitation.
Enner Alcântara +3 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Études Caribéennes, 2022 Since 2010, Haiti has been subject to many hazards. Earthquakes and cyclones have all caused significant damage to the building. However, in 2010, the observation of the impact of the earthquake had made it possible to make a clear distinction between ...
Thierry Joffroy +2 more
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Role of construction in managing disasters in developing economies [PDF]
Recent large scale natural disasters such as Indian Ocean Tsunami of December 2004 reminded the world that the natural disasters can occur at any time any place and there are no “safe heavens” in the world.
Amaratunga, Dilanthi +2 more
core +3 more sources
Tellus: Series B, Chemical and Physical Meteorology, 2019 In situ aircraft measurements of aerosols and clouds were performed over the eastern Loess Plateau in Shanxi Province, China. The microphysical properties of both aerosols and warm clouds, including aerosol number concentration (Na), particle effective ...
Junxia Li +5 more
doaj +1 more source
What Do Large Language Models Know About Materials?
Advanced Engineering Materials, EarlyView.If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer +2 more
wiley +1 more source