Results 21 to 30 of about 646,267 (312)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The Halal Tourism Trajectory, the Emergence and Challenge: The Case of Nanggroe Aceh Darussalam Post-2004 Tsunami

open access: yesHumaniora, 2021
Halal tourism has attracted a lot of attention in contemporary tourism and hospitality research. However, only a few studies have attempted to understand the emerging process and challenges in practicing halal tourism in a specific geographic location ...
Erda Rindrasih
doaj   +1 more source

Identification of disaster knowledge factors: preliminary findings [PDF]

open access: yes, 2010
Disasters bring about the loss of lives, property, employment and damage to the physical infrastructure and the environment. The number of reported disasters has increased steadily over the past century and risen very sharply during the past decade ...
Amaratunga, RDG   +3 more
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

Interpretable machine learning for flood susceptibility mapping in the metropolitan region of São Paulo, Southeast Brazil

open access: yesDiscover Geoscience
Accurate flood susceptibility modeling is critical for effective disaster risk management, particularly in rapidly urbanizing regions exposed to extreme precipitation.
Enner Alcântara   +3 more
doaj   +1 more source

Natural Disasters—Origins, Impacts, Management

open access: yesEncyclopedia, 2021
Natural hazards are processes that serve as triggers for natural disasters. Natural hazards can be classified into six categories. Geophysical or geological hazards relate to movement in solid earth.
Muhammad T. Chaudhary, Awais Piracha
doaj   +1 more source

Disasters and Disclosures [PDF]

open access: yes, 2018
Many securities fraud lawsuits follow corporate disasters of some sort or another, claiming that known risks were concealed prior to the crisis. Yet for a host of doctrinal, pragmatic and political reasons, there is no clear-cut duty to disclose these ...
Langevoort, Donald C
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

The Impact of Earthquakes on Apartment Owners and Renters in Te Whanganui-a-Tara (Wellington) Aotearoa New Zealand

open access: yesApplied Sciences, 2021
Apartment dwelling is on the increase in many cities in Aotearoa New Zealand, including those in earthquake-prone regions. Hence it is important that people working in disaster management and housing improve their understanding on how the living ...
Denise Blake   +3 more
doaj   +1 more source

Investigating the status of disaster management within a world-wide context: a case study analysis [PDF]

open access: yes, 2010
Disasters can be described as feats of spontaneous occurrences, in that they can happen at any minute at any time. There are two classifications of disasters, which are, natural disasters that cannot be predicted and continuously occur throughout ...
Alinden, CM   +2 more
core  

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