Results 41 to 50 of about 455,368 (271)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
The eggs of marine crabs - an unexploited resource [PDF]
, 2000 Marine crabs belonging to the family Portunidae form bycatch of shrimp trawlers in India. They are sold at low prices and consumers discard eggs and consume the meat.
Radhakrishnan, C.K.
core
, 2006 We show how applying field conjugated to the order parameter, may act as a very precise probe to explore the probability distribution function of the order parameter.
J.-P. Bouchaud +5 more
core +2 more sources
RTP control protocol (RTCP) extended report (XR) block for independent reporting of burst/fgp discard metrics [PDF]
, 2016 This document defines an RTP Control Protocol (RTCP) Extended Report (XR) block that allows the reporting of burst/gap discard metrics independently of the burst/gap loss metrics for use in a range of RTP ...
Clark, A. +3 more
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Uptake and barriers for implementation of the resect and discard strategy: an international survey
Endoscopy International Open, 2020 Background and study aims Optical real-time diagnosis (= resect-and-discard strategy) is an alternative to histopathology for diminutive colorectal polyps. However, clinical adoption of this approach seems sparse.
Philippe Willems +8 more
doaj +1 more source
Fake-Acknowledgment Attack on ACK-based Sensor Power Schedule for Remote State Estimation [PDF]
, 2015 We consider a class of malicious attacks against remote state estimation. A sensor with limited resources adopts an acknowledgement (ACK)-based online power schedule to improve the remote state estimation performance.
Dey, Subhrakanti +3 more
core +3 more sources
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Discard sampling of the Dutch pelagic freezer fishery in 2003-2007 [PDF]
This report contains the results of the discard sampling programme on the Dutch pelagic trawl fisheries in the North East Atlantic in the period 2003-2007, which was instigated as part of the EC regulation 1543/2000 and 1639/2001 on data collection in ...
Helmond, A.T.M., van +1 more
core +6 more sources