Results 41 to 50 of about 2,211 (209)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Uptake and barriers for implementation of the resect and discard strategy: an international survey

Endoscopy International Open, 2020
Background and study aims Optical real-time diagnosis (= resect-and-discard strategy) is an alternative to histopathology for diminutive colorectal polyps. However, clinical adoption of this approach seems sparse.
Philippe Willems, Roupen Djinbachian, Saskia Ditisheim, Sinan Orkut, Heiko Pohl, Alan Barkun, Mickael Bouin, Bernard Faulques, Daniel von Renteln   +8 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

No deleterious circumference effects for T90 codends in an Australian fish trawl targeting tiger flathead, Platycephalus richardsoni

Frontiers in Marine Science
In an attempt to improve the selectivity of Australian fish trawls targeting tiger flathead, Platycephalus richardsoni (≥28 cm total length), the utility of four-seam codends with shortened lastridge ropes and comprising 71-mm meshes turned 90° (T90 ...
Matt K. Broadhurst, Matt K. Broadhurst, Russell B. Millar   +2 more
doaj   +1 more source

Changes in the production and use of pottery from the Early Neolithic to the ‘secondary products revolution’: some evidence from LN Makriyalos, Northern Greece

Documenta Praehistorica, 2002
Recent developments in pottery studies have altered the way archaeologists handle and interpret prehistoric pottery. The technology and use of pottery, the symbolic and social meaning of the pot are considered as anthropological phenomena, the products ...
Dimitrios Vlachos
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A 5-year cross-sectional retrospective analysis of discard of blood and its components in the blood bank of a tertiary trauma center

Asian Journal of Transfusion Science
INTRODUCTION: Blood transfusion is an integral part of health-care system and there is no complete suitable substitute for human blood till date. Thus, every unit of blood and its products is precious and should be used judiciously.
Arundhathi Shankaralingappa, K Shanti Jyoti, Thirunavukkarasu Arun Babu   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Reducing Artisanal Fishery Impact on Marine Community: New Data from Comparison of Innovative and Traditional Gear

Fishes
Fishery resources overexploitation, together with bycatch and discards, have an impact on marine ecosystems. The adoption of technologically innovative gears is a possible solution to reduce the discard and to enhance the sustainability of fishery ...
Manfredi Madia, Massimiliano Bottaro, Tiziana Cillari, Andrea Li Vorsi, Luca Castriota, Maria Rita Amico, Sergio Bizzarri, Teresa Maggio, Manuela Falautano, Michele Gristina, Ilaria Di Lauro, Floriana Trova, Patrizia Perzia, Roberto D’Ambra, Enrico Casola, Mauro Sinopoli   +15 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source