Results 61 to 70 of about 22,300 (230)

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

Is preoperative occupation related to long-term pain in patients operated for lumbar disc herniation? Cirurgia de hérnia de disco lombar: existe relação entre a profissão e a persistência de dor?

Arquivos de Neuro-Psiquiatria, 2007
Lumbar disc herniation (LDH) is a common cause of back and sciatic pain. When clinical treatment fails, surgery may be indicated in selected patients. Although surgery is effective in most cases, some of these patients may have a poor outcome.
Daniel Benzecry Almeida, Paola Hesse Poletto, Jerônimo Buzetti Milano, André Giacomelli Leal, Ricardo Ramina   +4 more
doaj   +1 more source

Factors Affecting Outcomes in Anterior Cervical Spine Surgery

The Laryngoscope, Volume 136, Issue 7, Page 2963-2970, July 2026.
This retrospective cohort study examined perioperative complications after anterior cervical spine surgery (ACSS) in 3401 patients treated at a tertiary academic institution. Otolaryngologist co‐surgeons in revision and upper cervical spine (C1‐4) cases, and high‐volume spine surgeons (≥ 15 annual cases) were associated with lower complication rates ...
Nana‐Hawwa Abdul‐Rahman, Hansen Deng, Jonathan Goulazian, Cynthia McMahan, Peter C. Gerszten, Carl H. Snyderman   +5 more
wiley   +1 more source

Postoperative Wound Pain and Hospital Stay in Patients of Open Lumbar Discectomy (OLD) Versus Endoscopic Lumbar Discectomy (ELD) in Lumbar Disc Herniation (LDH)

, 2020
Background: Endoscopic lumbar discectomy is also beneficial regarding relieving wound pain, less hospital stay and smaller incisions. We compared visual analog scores (VAS) and hospital stay in patients treated with either endoscopic lumbar discectomy or
KAMBOOH, USMAN AHMED, RAZA, ASIF, AMIN, ADIL, ASHRAF, NAVEED, SHAHID, SAMAN, SHAHZAD HUSSAIN, SYED   +5 more
core   +1 more source

Metabolic Dysregulation of FC3 Fibrochondrocytes via MDH2 Promotes Intervertebral Disc Degeneration

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of chronic low back pain, yet the specific cell subpopulations and metabolic mechanisms driving its progression remain incompletely understood. We performed an integrative analysis of single‐cell RNA sequencing (scRNA‐seq) and transcriptomic sequencing using public datasets (GSE230809 ...
Xingye Li, Jinbao Tian, Zhongning Xu, Yan An, Jincheng Guo, Da He   +5 more
wiley   +1 more source

Analysis of reasons for failed surgery treatment in patients with back pain

Неврология, нейропсихиатрия, психосоматика, 2011
Fifty-three patients followed up for back pain and operated on are analyzed. The failed back surgery syndrome was observed in 47% of cases. Surgical results did not depend on the duration of the last exacerbation, the frequency of admissions, the ...
M. S. Kokina, E. G. Filatova
doaj   +1 more source

The Anterolateral Transpedicular Transverse Process Screw Technique: Surgical Techniques, Biomechanical study and Preliminary Outcomes

Orthopaedic Surgery, Volume 18, Issue 7, Page 1375-1397, July 2026.
This study designed a novel anterolateral screw placement technique and, based on this, developed a new anterolateral fixation method. Imaging, biomechanical, and short‐term efficacy analyses revealed that the Anterolateral Transpedicular Transverse Process Screw (ALTTS) technique achieves a high success rate for L5 vertebral fixation (pedicle width ...
Mingdong Zhang, Jiaqi Wang, Jin Chu, Xin Guo, Wei Zhang, Dapeng Feng, Zhengwei Li   +6 more
wiley   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 34, 19 June 2026.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology

JOR SPINE, Volume 9, Issue 2, June 2026.
A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou, Zerihun G. Workineh, Maria Segarra‐Queralt, Francis Kiptengwer Chemorion, Paola Bermudez‐Lekerika, Exarchos Kanelis, Katherine B. Crump, Benjamin Gantenbein, Leonidas G. Alexopoulos, Christine L. Le Maitre, Janet Piñero, Jérôme Noailly   +11 more
wiley   +1 more source

Surgical tricks for open lumbar discectomy

, 2017
Learning objectives • To explain the pathophysiology of herniated disc. • To show the clinical appearance, physical examination and surgical indication for S1 root radiculopathy. • To learn anatomy and surgical technique related to lumbar discectomy.
Perna, Fabrizio, Francesco Traina, Traina, Francesco, Fabrizio Perna, Cesare Faldini, Niccolò Stefanini, Borghi, Raffaele, Mohammadreza Chehrassan, Chehrassan, Mohammadreza, Raffaele Borghi, Stefanini, Niccolò, Faldini, Cesare   +11 more
core   +1 more source