Results 71 to 80 of about 38,279 (238)

The Implementation of Persistent Spinal Pain Syndrome (PSPS): Mechanism‐Based Recommendations

Pain Practice, Volume 26, Issue 1, January 2026.
ABSTRACT Background In 2021, the term persistent spinal pain syndrome (PSPS) was introduced. PSPS type 2 (PSPS‐T2) replaced the unsatisfactory term failed back surgery syndrome (FBSS). PSPS type 1 (PSPS‐T1) is a clinical picture of signs and symptoms of FBSS but without prior surgery. PSPS applies to any spinal level.
Simon Thomson, Brian Simpson, Frank J. Huygen, Michael Stanton‐Hicks, Richard B. North, Giancarlo Barolat, Harriet Scott, Rui V. Duarte   +7 more
wiley   +1 more source

Lactate Metabolism in Intervertebral Disc Degeneration: Unveiling Novel Mechanisms Through Bioinformatics

JOR SPINE, Volume 8, Issue 4, December 2025.
This graphical abstract outlines the workflow to uncovering lactate metabolism‐related mechanisms in intervertebral disc degeneration (IDD). First, three IDD datasets (GSE34095: 3 IDD vs 3 control; GSE147383: 2 IDD vs 2 control; GSE70362: 16 IDD vs 8 control) were sourced from the Gene Expression Omnibus (GEO) database, and 73 lactate metabolism ...
Haiyan Sun, Mingwei He, Jinlei Pang, Xiangfei Guo, Yansong Huo, Jun Ma   +5 more
wiley   +1 more source

Interleukin-6 Expression in Disc Derangement of Human Temporomandibular Joint and Association with Osteoarthrosis [PDF]

, 2017
The inflammatory process is a coordinated response that protects host after infection or trauma, involving several molecular reactions. Once the inflammation is closely linked to the process of destruction of the temporomandibular joint, this study aims ...
Almeida, Luis Eduardo, Ambros, Viviane, Azevedo, Marina, Camejo, Flavio, Caporal, Karina, Doetzer, Andrea, Noronha, Lucia, Olandoski, Marcia, Trevilatto, Paula C.   +8 more
core   +1 more source

The Impact of the Ovine Annular Lesion Model on IVD Pathobiology and Utility of the Ovine Spinal Model in Patho‐Anatomical Studies: A Historical Perspective

JOR SPINE, Volume 8, Issue 4, December 2025.
The ovine annular rim‐lesion model of intervertebral disc degeneration of Osti and colleagues (1990) has evolved into a sophisticated mechanical destabilization large animal model of intervertebral disc degeneration over its 35 year history offering diverse musculoskeletal multi‐disciplinary investigations into the multifunctional complexity of this ...
O. Osti, C. B. Little, J. Melrose
wiley   +1 more source

Fibrin-genipin adhesive hydrogel for annulus fibrosus repair: performance evaluation with large animal organ culture, in situ biomechanics, and in vivo degradation tests [PDF]

European Cells & Materials, 2014
Annulus fibrosus (AF) defects from annular tears, herniation, and discectomy procedures are associated with painful conditions and accelerated intervertebral disc (IVD) degeneration.
M Likhitpanichkul, M Dreischarf, S Illien-Junger, BA Walter, T Nukaga, RG Long, D Sakai, AC Hecht, JC Iatridis   +8 more
doaj  

Cervical Deformity Patients Have Baseline Swallowing Dysfunction but Surgery Does Not Increase Dysphagia at 3 Months: Results From a Prospective Cohort Study. [PDF]

, 2019
Study designProspective cohort study.ObjectivesMost studies of dysphagia in the cervical spine have focused on a degenerative patient population; the rate of dysphagia following surgery for cervical deformity (CD) is unknown.
Ames, Christopher P, Bao, Hongda, International Spine Study Group (ISSG), Iyer, Sravisht, Kim, Han Jo, Klineberg, Eric O, Lafage, Virginie, Mundis, Gregory M, Neuman, Brian J, Passias, Peter, Protopsaltis, Themistocles S, Smith, Justin S   +11 more
core  

Lovastatin‐Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle‐Puncture Induced Degeneration Model in Rat Caudal Discs

JOR SPINE, Volume 8, Issue 4, December 2025.
Lovastatin‐loaded nanoparticles were developed and incorporated into a thermosensitive chitosan hydrogel for treating intervertebral disc degeneration, showing sustained lovastatin release and enhanced production of aggrecan and Type II collagen in human nucleus pulposus cells in vitro. Animal studies using a rat caudal disc model mimicking early stage
Chih‐Wei Chen, Yung‐Hsin Cheng, Kai‐Chiang Yang, Chuan‐Ching Huang, Ming‐Hsiao Hu, Yuan‐Hui Sun, Jaw‐Lin Wang, Shu‐Hua Yang   +7 more
wiley   +1 more source

Clinical and Radiological Outcome in a Series of Patients Treated by Anterior Cervical Discectomy and Fusion: Retrospective Controlled Study With 2 Different Stand-Alone Cages [PDF]

, 2022
José Poblete, Jaime Jesús Martínez–Anda, Angel Asdrubal Rebollar - Mendoza, Yajaira Castro - Moreno, Ramón Torné, Luis Reyes, Salvador Fuster, Eduard Tornero, Emilo Arch-Tirado, Roberto de Leo-Vargas, Andrés Combalía, Joaquim Enseñat   +11 more
openalex   +1 more source

Out‐of‐Pocket Costs and Surprise Billing in Otolaryngology: A National Database Analysis

Otolaryngology–Head and Neck Surgery, Volume 173, Issue 6, Page 1393-1402, December 2025.
Abstract Objective To evaluate out‐of‐pocket (OOP) costs and surprise billing (unexpected charges from out‐of‐network providers) in otolaryngology. Study Design Retrospective cohort study. Setting National commercial claims database. Methods Merative MarketScan database was queried for commercially insured patients aged 18 to 64 who underwent any of ...
Nicholas R. Lenze, Chamila D. Perera, Karan R. Chhabra, John W. Scott, Raj C. Dedhia, Michael J. Brenner   +5 more
wiley   +1 more source

Hypopharyngeal Lymphangioma Causing Persistent Dysphagia in an Adult: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
Endoscopy and histology of hypopharyngeal mass. Endoscopic evaluation of Zenker's diverticulum (A) before and (B) after repair. (C) H&E stain of excised soft tissue mass reveals benign squamous mucosa with dilated lymphatic channels (red arrow). (D) Immunohistochemistry reveals the endothelial cells lining the channels are D2‐40 positive (red arrow ...
Maryann Zhao, Nabil F. Darwich, Erica R. Thaler   +2 more
wiley   +1 more source