Results 91 to 100 of about 9,999,831 (234)

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Epileptic arousals: A neglected clinical entity

Epilepsia, EarlyView.
Abstract Objective Epileptic arousals (EAs) are seizures characterized solely by arousal from sleep. EAs are unrecognized in current seizure classifications. Their subtle semiology and inconsistently detectable ictal activity in scalp electroencephalography (EEG) complicate differentiation from physiological arousals (PAs). This study characterizes EAs
Lea Fisel, Nóra Pető, Sotirios Kalousios, Nicolas Zabler, Armin Brandt, Peter C. Reinacher, Dieter Riemann, Mohammad F. Khazali, Andreas Schulze‐Bonhage   +8 more
wiley   +1 more source

Understanding patients’ decision to leave hospital care in Ghana: clinical cases and underlying determinants

BMC Nursing
Background The quality of patient discharge teaching and information influences most patients’ readiness for discharge and perceptions of care. Planned patient discharge positively impacts patient health outcomes and post-discharge care management ...
Abukari Kwame, Pammla M. Petrucka
doaj   +1 more source

Interictal epileptiform discharges on scalp electroencephalography: Reproducibility of visual interpretation—A systematic review

Epilepsia, EarlyView.
Abstract Objective Interictal epileptiform discharges (IEDs) are a key diagnostic finding in first seizure, early epilepsy, and acute brain dysfunction. Variability in visual electroencephalographic (EEG) analysis contributes to diagnostic uncertainty. We performed a systematic review of the reproducibility of IED detection in clinical EEG.
Jan Brogger, Eivind Aanestad, Sándor Beniczky, Viljami Kemppi, Bekir Burak Kılboz   +4 more
wiley   +1 more source

DISCHARGE AGAINST MEDICAL ADVICE IN PEDIATRIC INTENSIVE CARE UNIT AND SUBSEQUENT EVENTS

International Journal of Integrated Health Sciences, 2015
Objective: The occurence of discharge against medical advice (DAMA) has impacted globally. Decisions of DAMA in pediatric patients are not made by the patients, but pose life-threatening consequences, especially for children treated in Pediatrics ...
Dadang Hudaya Somasetia, Susanto Isman, Nathania Wonoputri   +2 more
doaj   +1 more source

Real world testing and cost‐effectiveness analysis of subcutaneous EEG (REAL‐ASE): Protocol for a prospective multicentre interventional trial

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a common condition associated with significant morbidity, mortality, and costs. Poor documentation of seizures is a major challenge in epilepsy care. Objective seizure counting with mobile devices may mitigate this challenge and improve patient management.
Matthew McWilliam, Pedro F. Viana, Eren Dursun, Joe Davies, Joel S. Winston, Jessica Agren, Harutomo Hasegawa, Jonas Duun‐Henriksen, Mark P. Richardson   +8 more
wiley   +1 more source

Factors Associated With Premature Discharge of Patients With Psychosis Against Medical Advice [PDF]

Iranian Journal of Psychiatry, 2006
Objective: This study was conducted to identify the characteristics of patients with psychosis who had escaped from hospital or were discharged prematurely and against medical advice.
P. Jafar Nejad, Mitra Monir Abbasi, Seyed Ali Ahmadi Abhari, H Zerrati   +3 more
doaj   +1 more source

Response to anti‐seizure medications in children carrying novel or previously reported HCN1 gene variants

Epilepsia Open, EarlyView.
Abstract Objective Variants in the HCN1 gene cause a syndrome of childhood epilepsy and developmental disability with a broad phenotypic range. Many affected children manifest with early infantile epileptic encephalopathy (EIEE) and highly drug‐resistant epilepsy.
Marium N. Khan, Nicholas P. Poolos
wiley   +1 more source

‘They Should Understand That the Anorexia Drives me to do Anything’: Exploring How Individuals With Anorexia Nervosa Make Sense of the Experience of Medical Admissions

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a complex disorder associated with significant morbidity and mortality. Some people with AN require medical admissions to manage physical complications. Currently, little is known about how these medical admissions are experienced, despite an increase in the number of individuals being hospitalised.
Hannah Webb, Penny Neild, Vanessa Lawrence, Ulrike Schmidt, Maria Griffiths   +4 more
wiley   +1 more source

Turning the TIDE: Paediatric Provider Perspectives on Implementing a Transition Intervention for Eating Disorders

European Eating Disorders Review, EarlyView.
ABSTRACT Objective This qualitative study aimed to explore paediatric providers' perspectives on the acceptability, feasibility, and appropriateness of the Transition Intervention for Eating Disorders (TIDE) within existing specialised paediatric eating disorder (ED) programs to inform its refinement and implementation in real‐world clinical settings ...
Maria Nicula, Melissa Kimber, Khrista Boylan, Jennifer Couturier   +3 more
wiley   +1 more source