Results 51 to 60 of about 3,205,369 (298)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating the Electrochemical Characteristics of Lithium Vanadium Phosphate Cathode Synthesized by the Solution Combustion Method Utilizing Cetyltrimethylammonium Bromide as a Fuel for Lithium-Ion Batteries Applications [PDF]

Journal of Advanced Materials in Engineering
Introduction and Objectives: Optimization of vanadium phosphate compounds through the control of synthesis methods plays a key role in enhancing their performance. In this research, the effect of adding cetyltrimethylammonium bromide with different molar
Mohammad Tahernejad Javazm, Masoud Hasheminiasari, Seyed Morteza Masoudpanah   +2 more
doaj   +1 more source

The assessment of drainage performance in the residential area using SWMM

Jurnal Ilmiah SINERGI, 2023
Flood is a general issue that can lead to the life and safety of residents. One of the problems is the lack of capacity in the drainage system in a residential area.
Yuliastuti Juliastuti, Timotius Kurniawan Wihartono, Oki Setyandito, Yureana Wijayanti, Lisma Safitri, Ika Sari Damayanti Sebayang   +5 more
doaj   +1 more source

Missouri Work Zone Capacity: Results of Field Data Analysis, TPF-5(081), 2011 [PDF]

, 2011
This report presents the results of work zone field data analyzed on interstate highways in Missouri to determine the mean breakdown and queue-discharge flow rates as measures of capacity.

core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Analysis of discharge rates in rectangular slit, ogee, and sharp-crested weirs

Frontiers in Built Environment
Climate change has made flash floods increasingly common. It's crucial to have confidence in the structural integrity of dams during a flash flood. According to the International Commission on Large Dams (ICOLD), approximately one-third of dam failures ...
Hossein Sohrabzadeh Anzani, Ali Mahdian Khalili, Sameh Ahmed Kantoush, Mehdi Hamidi   +3 more
doaj   +1 more source

Modeling discharge capacity of labyrinth weirs through a learning machine approach [PDF]

Journal of Applied Research in Water and Wastewater, 2019
In this paper, the discharge coefficient of weirs is simulated by the extreme learning machine (ELM). To this end, seven different ELM models are introduced by the input parameters.
Mohammadali Izadbakhsh, Reza Hajiabadi
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source