Results 41 to 50 of about 232,000 (307)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Testing of technique for seawater filtration at fish farms
Известия ТИНРО, 2014 Seawater filtration is tested on the experimental stand with 10 types of single- and double-layer filters for water samples collected in 3 sites with different environments in the Severnaya Bay (Peter the Great Bay, Japan Sea).
Alexandra I. Fedorovа +1 more
doaj +1 more source
Free Flow Capacity and Queue Discharge Rate: Long-Term Changes
, 2022 Traffic jams are caused by a traffic demand that exceeds road capacity. Road capacity, therefore, is an important road feature. This capacity might change as function of time, even for the same road stretch, owing to changing driving behaviors or vehicle
Knoop, V.L. (author) +1 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Frontiers in Chemistry, 2021 Lithium argyrodite Li6PS5Cl powders are synthesized from Li2S, P2S5, and LiCl via wet milling and post-annealing at 500°C for 4 h. Organic solvents such as hexane, heptane, toluene, and xylene are used during the wet milling process. The phase evolution,
Jae Min Lee +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Analysis of discharge rates in rectangular slit, ogee, and sharp-crested weirs
Frontiers in Built EnvironmentClimate change has made flash floods increasingly common. It's crucial to have confidence in the structural integrity of dams during a flash flood. According to the International Commission on Large Dams (ICOLD), approximately one-third of dam failures ...
Hossein Sohrabzadeh Anzani +3 more
doaj +1 more source
A Bilevel Equalizer to Boost the Capacity of Second Life Li Ion Batteries
Batteries, 2019 There is a strong interest in second life applications for the growing number of used electric vehicle (EV) batteries, but capacity variations amongst these used cells present a problem.
Ngalula Sandrine Mubenga +2 more
doaj +1 more source