Results 71 to 80 of about 3,205,369 (298)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Comparison of the Impact of Akmon, Sta-bar, Sta-pod, Stock cube, and Tribar Armoring Layers on the Level of Flow Rate and Wave Overtopping [PDF]

Journal of Hydraulic and Water Engineering
Breakwaters are structures whose main function is to reduce waves in an area and create a calm basin for the stopping, movement, and maneuvering of floating objects.
Ali Safari, Mehdi Behdarvandi Askar
doaj   +1 more source

II. On stratified discharges. V. Discharge from a condenser of large capacity [PDF]

Proceedings of the Royal Society of London, 1878
Abstract The principal object of the following communication is to describe an instrumental arrangement which has proved very convenient for the production of steady striæ. The first attempt which was made nearly two years ago (February, 1876), consisted in charging a Leyden battery of nine large jars by means of an induction coil ...
openaire   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Discharge Capacity of Prefabricated Vertical Drain Confined in-clay

Geosynthetics Engineering Journal, 2000
This paper reports the long-term discharge capacities of four types of prefabricated vertical drains (PVDs) confined in clay. The results indicate that under clay confinement, the PVD discharge capacities significantly reduced with time. The discharge capacity reduction may be caused by creep deformation of the PVD filter or clogging of the drainage ...
Miura, N., Chai, J. C.
openaire   +2 more sources

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes, Leonardo Cruz‐Criollo, Eric Kontowicz, Marta Olivé‐Gadea, Francesco Diana, Johannes Kaesmacher, Adnan Mujanovic, Serdar Geyik, Songul Senadim, Amedeo Cervo, Andrea Salcuni, Mariangela Piano, Manuel Moreu, Alfonso López‐Frías, Ameer E. Hassan, Samantha Miller, Elena Zapata‐Arriaza, Asier de Albóniga‐Chindurza, Mauro Bergui, Stefano Molinaro, João André Sousa, Fábio Gomes, João Sargento‐Freitas, Andrea Alexandre, Alessandro Pedicelli, Jeremy Hofmeister, Paolo Machi, Luca Scarcia, Erwah Kalsoum, Jose Amorim, Torcato Meira, Leonardo Renieri, Francesco Capasso, Daniele Romano, Eduardo Bárcena‐Ruiz, David Seoane, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Catarina Perry da Câmara, Anderson Brito, Nashwa Abdelhakim, Isabel Fragata, Dileep R. Yavagal, Jude H. Charles, Jose Rodriguez Castro, Pedro Vega, Atilla Özcan Özdemir, Zehra Uysal Kocabaş, Stanislas Smajda, Sadiq Al Salman, Jane Khalife, Tudor G. Jovin, Francesco Biraschi, Francesca Richetti, Pedro Castro, Luis Albuquerque, Adnan Siddiqui, Vinay Jaikumar, Pedro Navia, Nikolaos Ntoulias, Marios Psychogios, Mariano Velo, Joaquín Zamarro, Gonzalo de Paco, Yazan Ashouri, Mohammad AlMajali, Juan F. Arenillas, Alicia Sierra, Michele Romoli, João Pedro Marto, Shadi Yaghi, Marc Ribo, Alejandro Tomasello, Manuel Requena, Santiago Ortega‐Gutierrez   +75 more
wiley   +1 more source

The Electrochemical Performances of n-Type Extended Lattice Spaced Si Negative Electrodes for Lithium-Ion Batteries

Frontiers in Chemistry, 2019
The electrochemical performances of lithium-ion batteries with different lattice-spacing Si negative electrodes were investigated. To achieve a homogeneous distribution of impurities in the Si anodes, single crystalline Si wafers with As-dopant were ball-
Moonsang Lee, Dockyoung Yoon, Dockyoung Yoon, Uk Jae Lee, Nurzhan Umirov, Aliya Mukanova, Zhumabay Bakenov, Sung-Soo Kim   +7 more
doaj   +1 more source

The Transport Sector : A Laboratory for Good Practices in Capacity Development?

, 2006
As articulated in the Paris Declaration on Aid Effectiveness (2005), country capacity is at the core of sustainable development.
Davis, Deborah
core   +1 more source

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias, Federica Avantaggiato, Gianni Pezzoli, Andrea Canessa   +3 more
wiley   +1 more source

Anfis to estimate discharge capacity of rectangular side weir

Proceedings of the Institution of Civil Engineers - Water Management, 2013
The adaptive neuro-fuzzy inference system (Anfis) is considered for flow over rectangular side weirs located on a straight channel as a substantial part of distribution channels in irrigation systems and treatment units. To estimate the outflow over a rectangular sharp-crested side weir, the discharge coefficient in the side weir equation needs to be ...
Kisi, Ozgur, Bilhan, Omer, Emiroglu, M. Emin   +2 more
openaire   +2 more sources